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時系列ネットワークにおけるランキング変動要因推定と炎症進行分析への応用

时间序列网络中排序变异因素的估计及其在炎症进展分析中的应用

基本信息

批准号：
22K12043
负责人：
浅野泰仁
金额：
$ 2.58万
依托单位：
Toyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2022
资助国家：
日本
起止时间：
2022-04-01 至 2025-03-31
项目状态：
未结题

项目摘要

令和4年度は，これまで研究してきた遺伝子相関ネットワークの適用データの拡大と，その上でのネットワーク分析手法の開発に取り組んだ．適用データの拡大については，新たに筑波大学・島野研究室で作成された2型糖尿病モデルマウスの膵島から得られた単一細胞遺伝子発現データを対象とした．ネットワーク分析手法としては，以下の3種類を提案した．(1) Webコミュニティ抽出手法であるLouvain法を遺伝子相関ネットワークに応用し，炎症進行時に相互作用している可能性の高い遺伝子群(クラスタ)を検出する手法 (2) Web関連ページ発見手法であるPersonalized PageRankを遺伝子相関ネットワークに応用して，炎症進行時に与えられた特定遺伝子と相互作用している可能性の高い遺伝子をランキングする手法 (3) 時系列ネットワークから連関ルールを発見する手法である．(1)の手法については，東京理科大学・松島研究室で作成された珪素誘導肺線維症マウスから得られたデータにこれを適用し，炎症進行につれて遺伝子群が大きく変化していくことがわかった．またそれぞれのクラスタにおいて生物学的検証を行ったところ，炎症進行に重要な働きをしている既存の相互作用群が多く含まれることを発見した．(2)の手法については，上記の2型糖尿病モデルマウスのデータにおいて，島野研究室で炎症進行メカニズムに重大な影響を持つ可能性が高いと特定したある遺伝子についてこれを適用し，その遺伝子とβ細胞の関連を裏付ける成果を上げた．本成果については島野研究室の研究結果と合わせて論文誌に投稿中である．(3)の手法については，別種のデータとして東京湾プランクトン出現数データから時系列ネットワークを作成して適用し，水産研究・教育機構の長井氏らと論文をまとめ，論文誌Metabarcoding and Metagenomicsに採録された．

In the year of 2004, the research and development of the system was carried out in the first half of the year, and the data acquisition system was opened in the first half of the year. In the end of the year, in the fourth year of the year, in the year of 2004, in the year of 2004, the study was conducted in the first half of the year. The new laboratory of the University of Tsukuba is responsible for the treatment of type 2 diabetes. the results of the laboratory of the University of Tsukuba are as follows: the laboratory of the University of Tsukuba has been established in the new laboratory of the University of Tsukuba. (1) the method of extraction of Web, the method of extraction, the method of During the progression of inflammation, the possibility of chronic interaction is high, and the subgroup is highly likely to detect the manipulation of the disease. (2) the technique of Web is not known to be used. It is known to be used in the treatment of Personalized PageRank infection. During the progression of inflammation, there is a high possibility of interaction with specific antigens. (3) when the inflammation is in progress, there is a high possibility of interaction between the inflammation and the specific substrates. (1) the manipulation is not effective. The laboratory of the pine laboratory of Beijing University of Science and Technology has been established as a tool for the treatment of lung disease. Inflammation occurs in the subgroup of the lung, the subgroup of the lung and the inflammation of the lung. In the process of inflammation, there are many existing interaction groups. (2) the manipulation of diabetes mellitus (type 2 diabetes mellitus). It is noted that the inflammation of type 2 diabetes mellitus (type 2 diabetes) is very important, and that in the field laboratory is very important. The results of this study are in line with the results of the field study. (3) the results of the study are in accordance with the results of the contributions. (3) the results of the study are in line with the results of the research in the field research lab. (3) the results of the study are in accordance with the results of the submission of the paper. (3) the results of the study show that the results of the study are in accordance with the results of the study. (3) the results of the study are in accordance with the results of the submission. (3) the results of the study are in accordance with the results of the submission. (3) the results of the study are in accordance with the results of the submission. (3) the results of this study are in accordance with the results of the submission. (3) the results of the study are similar to those of the submitted papers. The Institute of Water Resources Research and Education is responsible for the study of the literature of Nagai and the Metabarcoding and Metagenomics of literature and magazines.