らせん反転可能なペプチドからなる多孔質結晶

多肽螺旋是生物界中的一种常见结构。它在发生在细胞膜上的各种细胞过程中起着至关重要的作用，如信号传递和货物转运。为了模拟细胞膜中肽螺旋的动态变化，我开发了一种名为AibMOF的合成类似物。这种类似物是由充当支柱的多肽组成的晶体框架。框架中的多肽以特定的距离隔开，以允许动态运动。通过核磁共振波谱，我能够观察到多肽在多肽框架内的动态螺旋反转。此外，通过交换框架内的客体分子，我可以控制多肽的运动。

Peptide helix is a common structure found in the biological world. It plays a crucial role in various cellular processes, such as signal transmission and cargo transfer, that take place on the cell membrane. To mimic the dynamics of peptide helix in the cell membrane, I have developed a synthetic analogue known as AibMOF. This analogue is a crystalline framework made up of peptides acting as pillars. The peptides in the framework are spaced apart by specific distances to allow for dynamic movement. Through NMR spectroscopy, I was able to observe the dynamic helix inversion of peptides within the peptide framework. Furthermore, by exchanging the guest molecules inside the framework, I could control the movement of the peptides.