らせん反転可能なペプチドからなる多孔質結晶

由螺旋可逆肽组成的多孔晶体

• 批准号: 22KJ1165
• 负责人: YUAN WEI
• 金额: $ 1.6万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2023
• 资助国家: 日本
• 起止时间: 2023-03-08 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ1165/
• 关键词: Peptide Helix; Peptide Dynamics

Peptide helix is a common structure found in the biological world. It plays a crucial role in various cellular processes, such as signal transmission and cargo transfer, that take place on the cell membrane. To mimic the dynamics of peptide helix in the cell membrane, I have developed a synthetic analogue known as AibMOF. This analogue is a crystalline framework made up of peptides acting as pillars. The peptides in the framework are spaced apart by specific distances to allow for dynamic movement. Through NMR spectroscopy, I was able to observe the dynamic helix inversion of peptides within the peptide framework. Furthermore, by exchanging the guest molecules inside the framework, I could control the movement of the peptides.

肽螺旋是生物界中常见的结构。它在细胞膜上发生的各种细胞过程中发挥着至关重要的作用，例如信号传输和货物转移。为了模拟细胞膜中肽螺旋的动力学，我开发了一种称为 AibMOF 的合成类似物。该类似物是由作为支柱的肽组成的晶体框架。框架中的肽以特定距离间隔开，以允许动态运动。通过核磁共振波谱，我能够观察到肽在肽框架内的动态螺旋反转。此外，通过交换框架内的客体分子，我可以控制肽的运动。

项目成果

Helical Inversion Dynamics in a Metal-Peptide Framework

金属肽框架中的螺旋反转动力学

• 发表时间: 2022
• 作者: Wei Yuan;Hiroshi Sato;Takuzo Aida
• 通讯作者: Takuzo Aida