らせん反転可能なペプチドからなる多孔質結晶

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Peptide helix is a common structure found in the biological world. It plays a crucial role in various cellular processes, such as signal transmission and cargo transfer, that take place on the cell membrane. To mimic the dynamics of peptide helix in the cell membrane, I have developed a synthetic analogue known as AibMOF. This analogue is a crystalline framework made up of peptides acting as pillars. The peptides in the framework are spaced apart by specific distances to allow for dynamic movement. Through NMR spectroscopy, I was able to observe the dynamic helix inversion of peptides within the peptide framework. Furthermore, by exchanging the guest molecules inside the framework, I could control the movement of the peptides.