BRAIN/GUT AXIS--METHODS TO EXAMINE PEPTIDE DYNAMICS

神经肽是一种化学信使，其在中枢神经系统中的功能尚不清楚。通过在一个重要的时间过程中对多肽系统进行灵敏的局部分析的方法，将极大地增强对神经肽的生理功能的理解。这些信息与经典(胺、氨基酸)神经调节系统的数据结合在一起，可以提供有关DVC中作用的化学信使相互作用的关键信息。了解多肽的功能及其与胺能系统的相互作用为了解与大脑系统(情绪激动、寒冷暴露、手术、创伤、脓毒症、烧伤和功能性肠道疾病)相关的胃肠道病理提供了神经生理学模板，并可能影响未来的治疗策略。研究人员未来的目标包括将匹兹堡研究小组学到的技术应用于有意识的动物模型的研究，在那里可能会研究行为的影响。慢性留置骨髓记录阵列的植入通常在毗邻的实验室进行(乔·特拉弗斯博士-俄亥俄州立大学)。使微透析技术适应这些优雅的模型是一个研究目标。

Neuropeptides are chemical messengers whose function in the CNS remain unclear. The understanding of physiologic functions of neuropeptides would be greatly augmented by methods allowing sensitive, local analysis of multiple peptide systems over a significant time course. This information, taken together with data from classical (amine, amino acid) neuromodulator systems can provide critical information regarding interactive effects of chemical messengers acting at the DVC. Understanding peptide function and their interaction with aminergic systems provides the neurophysiologic template to understanding gastrointestinal pathologies related to cerebral systems (emotional agitation, cold exposure, surgery, trauma, sepsis, burns and functional bowel disorders), and could impact future therapeutic strategies. Future aims of the investigator include the application of the technology learned with the Pittsburgh groups to the study of conscious animal models, where behavioral influences may be studied. Implantations of chronic indwelling medullary recording arrays is routinely performed in an adjoining laboratory (Dr. Joe Travers-Ohio State). Adaptation of microdialysis technology to these elegant models is a research goal.