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Chemically Modified Nanoporous Titanium Oxide for Biomedical Applications

用于生物医学应用的化学改性纳米多孔氧化钛

基本信息

批准号：
52015780
负责人：
Professor Dr. Klaus von der Mark, Ph.D.
金额：
--
依托单位：
Lehrstuhl für Experimentelle Medizin I - Molekulare Pathogeneseforschung
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2008
资助国家：
德国
起止时间：
2007-12-31 至 2011-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/52015780?language=en
关键词：
Chemically Modified Nanoporous Titanium Oxide

项目摘要

Due to their high biocompatibility, titanium and titanium alloys are currently used in medical technology as superior biomedical implant materials. Modifications of the surface chemistry and the nanoscale structure of the surface oxide are of crucial significance for integration and biocompatibility of such implants into living environments of human or animal bodies. The present project intends to use porous titanium oxide layers (particularly vertically orientated TiO2 nanotube layers) and aims at grafting self - assembled organic monolayers (SAMs) with cell adhesive proteins, adhesive peptides and growth factors (cell growth supporting molecules = CGSM) as surface coatings in order to modify surface chemistry and morphology for optimizing the biocompatibility of the material. In particular we will exploit the open volume of the nanotubes to achieve a high filling density of cell growth supporting factors. Cellular responses to the coated nanoporous titanium oxide surfaces such as adhesion, spreading, morphology, proliferation and differentiation will be investigated with established in vitro methods. These modified titanium oxide surfaces will be used to spatially confine, align and guide cells by creating a chemically and structurally defined cellular biosystem where cell interactions and cellular activities can be monitored and controlled. The information gained from these studies will have an instantaneous impact on industrial application and development, in particular in life sciences industry for the production of highly biocompatible surfaces on titanium used as orthopedic and dental implants in replacement surgery.

钛及钛合金具有良好的生物相容性，是目前医疗技术中使用的上级生物医用植入材料。表面氧化物的表面化学和纳米级结构的改性对于将这种植入物整合到人或动物体的生活环境中和生物相容性具有至关重要的意义。本项目旨在使用多孔氧化钛层（特别是垂直取向的TiO 2纳米管层），并旨在用细胞粘附蛋白、粘附肽和生长因子（细胞生长支持分子= CGSM）作为表面涂层接枝自组装有机单层（SAM），以改变表面化学和形态，从而优化材料的生物相容性。特别地，我们将利用纳米管的开放体积来实现细胞生长支持因子的高填充密度。细胞反应的涂层纳米多孔氧化钛表面，如粘附，蔓延，形态，增殖和分化将与建立在体外方法进行了研究。这些改性的氧化钛表面将用于通过创建化学和结构定义的细胞生物系统来空间限制，排列和引导细胞，其中可以监测和控制细胞相互作用和细胞活性。从这些研究中获得的信息将对工业应用和发展产生即时影响，特别是在生命科学行业中，用于在钛上生产高度生物相容性表面，用于替代手术中的骨科和牙科植入物。