Development and application of ion mobility spectrometry.

离子迁移谱分析技术的发展与应用。

• 批准号: 59430008
• 负责人: HATANO Hiroyuki
• 金额: $ 20.16万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1984
• 资助国家: 日本
• 起止时间: 1984 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-59430008/
• 关键词: Ion Mobility Spectrometry (IMS); Reduced Drift Constant; Supercritical Fluid Chromatography; SFC-IMS; GC; SFC-IMS-QMS; 高分子液晶カラム; IMS-QMS

Fundamental study and development of the atmospheric pressure ion mobility spectrometry (IMS) was carried out.Carbon dioxide, reported not suitable for the medium in ion mobility study, was applied to the carrier gas and drift gas in IMS. Both positive and negative ions of carboxylic acid esters gave similar spectrum as obtained in nitrogen drift gas except the very low mobility due to the formation of cluster ions.Reduced mobility of various compounds such as nitrogen containing heterocyclic compounds, polyaromatics, alkylamine, amino acid and carboxylic acid esters etc. have been studied in relation to the molecular size and shape. A single peak method is used to calculate a resolution value equal to the theoretical number of peaks that can be separated prior to the peak from which the measurements are made. To predict selectivity of an ion mobility detector for GC and SFC, a term "reduced drift constant" was defined. With this value, ion mobility separation between two ions can be predicted from literature data.A capillary supercritical fluid chromatograph (SFC) with on-column UV detector and IMS was constructed. Carbon dioxide was used as both the chromatographic mobile phase and the ion mobility drift gas. Ion mobility spectra at appropriate chromatographic retention times produced distinct spectra for each of the compounds. The high sensitivity of ion mobility detection over UV detection can be achieved.New polyacrylic liquid crystalline compounds were synthesized as selective liquid phases for capillary column in GC and SFC.Quadrupole mass spectrometry was combined after the IMS drift tube and constructed the GC/SFC-IMS-QMS instrument to develop a system which can achieve highly selective and sensitive detection.

对大气压离子迁移谱（IMS）进行了基础研究和发展，将不适合作为离子迁移研究介质的CO2作为IMS的载气和漂移气。羧酸酯的正离子和负离子的光谱与氮漂移气中的光谱相似，只是由于簇离子的形成而导致迁移率很低.本文研究了含氮杂环化合物、多环芳烃、烷基胺、氨基酸和羧酸酯等化合物的约化迁移率与分子大小和形状的关系.使用单峰法计算分离度值，该分离度值等于在进行测量的峰之前可以分离的峰的理论数量。为了预测GC和SFC的离子迁移率检测器的选择性，定义了术语“约化漂移常数”。利用该值可以预测两种离子之间的离子迁移率分离。二氧化碳用作色谱移动的相和离子迁移漂移气体。在适当的色谱保留时间下的离子迁移谱为每种化合物产生了不同的光谱。合成了新型聚丙烯酸类液晶化合物作为毛细管色谱柱和超临界流体色谱柱的选择性液相，并将四极杆质谱联用在离子迁移谱漂移管之后，构建了GC/SFC-IMS-QMS仪器，实现了高选择性和高灵敏度的检测。

项目成果

S.Rokushika: Anal.Chem.59. 8-12 (1987)

S.Rokushika：Anal.Chem.59。

質量分析. 32-5. (1984)

质谱法。32-5。

S. Rokushika: Chromatographia. 22. 209-212 (1986)

S. Rokushika：色谱法。

S.Rokushika: "Prediction of ion separation from literature data for the ion mobility detector." J.Chromatogr.356. 393-399 (1986)

S.Rokushika：“根据离子淌度检测器的文献数据预测离子分离。”

S.Rokushika: Anal.Chem.58. 361-365 (1986)

S.Rokushika：Anal.Chem.58。