Research for the establishment of combined modality therapy including targeting chemotherapy for cancer of the pancreas.

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1. Twelve cultured human pancreatic cancer cell lines were established and it was demonstrated that they were good model of human pancreatic duct cell cancer.2. Anti-tumor chemo and radio sensitivity test of pancreatic cancer1) Pancreatic cancer cell lines showed good responses to anti-tumor drugs at clinically achievable concentration2) Pancreatic cancer, though resistant to irradiation, to irradiation at high irradiation dose level with the use of hypoxic cell sensitizer showed elevated response PK-23.3. Monoclonal antibody F-30 which specifically reacted with human pancreatic cancer was produced. Pancreatic cancer associated antigen detected by McAb F-30 was cell membrane integrated protein with molecular weight of 190,000 dalton.4. Analysis of <^(131)I> -labeled antibody F30 to detect tumor localization was performed.5. Human derives anti-human pancreatic cancer antibody was obtained using EB virus transformed B cell lines established from regional lymph node cells. But this B cell line was unstable about their ability to secrete antibody.6. Pancreatic cancer call clustes were detected in cytology from perfusate of gastroduodenal artery in resected specimen.7. Anti-tumor chemoshsitivity test was performed using ADM encapsulated in liposome and it was shown that encapsulated ADM was less effective than free ADN.