Studies on Impurity, Decomposition and Biotransformation of Volatile Anesthetics

七氟醚和异氟醚是新开发的挥发性麻醉药。我们研究了这些麻醉药与钠盐的稳定性以及它们的生物转化程度。结论：1.异氟烷、七氟烷、氟烷、甲氧基氟烷、安氟醚在紫外线照射下稳定两年。用离子色谱法测定了吸入氟烷过程中和吸入氟烷后兔和大鼠胆汁中的三氟乙酸。与氟烷的厌氧代谢产物&lt；CF2&gt；CHCl和&lt；CF3&gt；&lt；CH2&gt；Cl不同，三氟乙酸的排泄量在不同浓度下保持不变。用离子色谱法在吸入异氟醚过程中和吸入异氟醚后的兔胆汁中检测到三氟乙酸。三氟乙酸的排泄量呈剂量依赖性增加。无机氟呈剂量依赖性增加，吸入异氟烷1MAC×1小时后排泄量约为1m ol。作为异氟醚代谢产物的无机氟和有机氟在人体内的半衰期分别为29小时和39小时。计算出作为七氟醚代谢物的无机氟在人体内的半衰期为34小时。七氟醚与纯碱反应生成5个降解产物。这些产物为脱氢氟七氟醚、其甲基化产物和甲基化产物的3种脱氢氟产物。

Sevoflurane and isoflurane are newly developed volatile anesthetics. We studied on the stability of these anesthetics with sodalime and an extent of their biotransformation.1. Isoflurane, sevoflurane, halothane, methoxyflurane, and enflurane were stable under ultra-violet-ray exposure for two years.2. Trifluoroacetic acid was detected in the bile of rabbits and rats during and after inhalation of halothane by ionchromatography. Unlike <CF_2> CHCl and <CF_3> <CH_2> Cl, anearobic metabolites of halothane, the excretion of trifluoroacetic acid remained unchanged at each concentration of halothane.3. Trifluoroacetic acid was detected in the bile of rabbits during and after inhalation of isoflurane by ionchromatography. The excretion of trifluoroacetic acid increased dose dependently.4. The inorganic fluoride increased dose relatedly and approximately im mol was excreted after 1 MAC x hour inhalation of isoflurane.5. The half-lives of inorganic and organic fluoride as metabolites of isoflurane in man was calculated to be 29 and 39 hours, respectivery.6. The half-life of inorganic fluoride as metabolites of sevoflurane in man was calculated to be 34 hours.7. Sevoflurane reacted with sodalime to produce 5 degraded products. These products were a dehydrofluorinated sevoflurane, its methylated product and 3 kinds of dehydrofluorinated products of the methylated product.