Studies on the Drug-Receptor Mechanisms of Chemical Transmitters and Autacoids

我们团队的研究涉及各种激动剂的剂量-反应曲线与受体结合之间的关系，受体亚型的分类，激动剂的脱敏机制和受体在疾病动物中的功能。1. 乙酰胆碱受体的研究：Kawashima阐明了豚鼠回肠上的<M_2> -受体。Watanabe显示乙酰胆碱诱导虹膜平滑肌释放松弛物质。Takayanagi在药效和受体结合方面显示了激动剂活性的变化。吉田估计了<M_2> -毒蕈碱受体的3个结合部分。Gomi分析了激动剂的活性，Ca. udda分析了乙酰胆碱对单个平滑肌细胞脱敏的机制。木村证实了糖尿病小鼠乙酰胆碱受体的变化。2. 受体在血管中的作用机制：Tomita证明了K传导抑制< α >和< β >受体的机制。Toda阐明了人和猴冠状动脉组胺受体的亚型。石田证实了兔基底动脉嘌呤能受体的亚型。Kasuya表明，糖尿病大鼠肾上腺素活性升高的因素之一是内皮介导的血管舒张。3. 类自体细胞的受体机制：Kuriyama对豚鼠肺动脉组织组织的亚型进行了分类。久保田在豚鼠胆囊上展示了胆囊收缩素受体。Fukuda估计了GABA受体和Cl通道在培养小鸡脊髓神经元上的关系。

The studies of our team deal with the relationship between dose-response curves and receptor bindings for variou agonists, the classification of receptor-subtypes, the desensitization mechanisms for agonists and the receptor functons in the disease animals. 1. Studies on ACh receptors: Kawashima clarified the <M_2> -receptor on the guinea-pig ileum. Watanabe showed the release of relaxing subustnces from iris smooth muscle induced by ACh. Takayanagi showed the changes of agonist activities by efficacy and receptor binding. Yoshida estimated the 3 binding portions of <M_2> -muscarinic receptor. Gomi analyzed the activity of agonists and Ca. Utida showed the mechanisms of ACh desensitization on the single smooth muscle cells. Kimura demonstrated the change of ACh receptors in the diabete mice. 2. The receptor mechanisms on the blood vessels: Tomita demonstrated the inhibitoy mechanisms of <alpha> and <beta> receptors by K conductance. Toda clarified the subtypes of histamine receptors on the coronary arteies from man and monkey. Ishida demonstrated the subtype of purinergic receptors on rabbit basilar artery. Kasuya showed that one of factors in the augmentation of adrenaline activity of the diabate rats was due to the endothelium-mediated vasodilation. 3. Receptor mechnisms of autacoids: Kuriyama classified the subtypes of histamie on the lung artery from guinea-pig. Kubota demonstrated the receptor of cholecystokinin on the ginea-pig gall bladder. Fukuda estimated the relationship between the GABA receptor and Cl channel on the cultured chick spinal cord neurons.