Quiet sleep is for repair, active sleep is for learning

睡眠被认为具有许多不同的功能，从清除大脑废物到调节情绪和感知。了解动物模型的睡眠功能一直很困难，因为睡眠通常被简化为单一状态。我们对果蝇不同睡眠阶段的发现为研究不同的保守睡眠功能是如何被调节的提供了一种有力的方法。该项目将使用新的策略来操纵果蝇的睡眠阶段，以了解它们各自的生理和功能。我们将测试我们的假设，即不同类别的睡眠功能已经被进化划分到不同的阶段：一个主要与大脑修复有关的安静阶段和一个重要的学习活跃阶段。

Sleep is thought to achieve many different functions, from brain waste clearance to regulating emotions and perception. Understanding sleep functions in animal models has been difficult because sleep has been typically reduced to a single state. Our discovery of distinct sleep stages in the fruit fly provides a powerful way to study how different conserved sleep functions are regulated. This project will use new strategies for manipulating sleep stages in flies to understand their respective physiology and functions. We will test our hypothesis that different categories of sleep functions have been segregated by evolution into different stages: a quiet stage concerned primarily with brain repair and an active stage important for learning.