NightWare Therapeutic Platform for improving Cardiovascular Health inAdults With Nightmares Associated with PTSD

NightWare 治疗平台可改善患有 PTSD 相关噩梦的成年人的心血管健康

基本信息

  • 批准号:
    10559634
  • 负责人:
  • 金额:
    $ 19.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-02-01 至 2025-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Post traumatic stress disorder (PTSD) is linked to accelerated aging and is associated with increased risk of early-onset cardiovascular disease (CVD) in both men and women. PTSD is associated with premature vascular aging (i.e., large elastic arterial stiffening and vascular endothelial dysfunction) and autonomic dysfunction (e.g., reduced cardiovagal baroreflex sensitivity [cBRS] and heart rate variability [HRV]), key antecedents in the development of CVD. Sleep is important for cardiovascular health via cellular and tissue repair, free radical detoxification and reducing oxidative stress and inflammation. Nightmares, a central feature of PTSD, are a debilitating condition that can lead to sleep deprivation or insomnia, daytime sleepiness and other sequala, that ultimately causes clinically significant distress and impairment in social, occupational and cardiovascular function. As such, therapeutic strategies and interventions that address nightmare-associated sleep disturbances in individuals with PTSD is clinically important for improving sleep quality, cardiovascular health and risk for future age-associated CVD. NightWare™ digital therapeutic system is a novel smart watch application that was recently granted Breakthrough Device designation by the FDA for the treatment of nightmares in adults with PTSD. It uses machine learning to detect, track and arouse an individual out of a nightmare by sending vibrotactile feedback to a smart watch, and arousing the individual out of the nightmare without awakening and disrupting sleep. In the present R21 we are proposing a randomized, double-blind, placebo (i.e., sham intervention) controlled parallel pilot study that will provide the first clinical evidence for the efficacy of the NightWare digital therapeutic system to improve cardiovascular health outcomes in adults with nightmares associated with PTSD. An additional goal of this R21 will be to obtain exploratory mechanistic insight by which NightWare improves cardiovascular function, specifically, related to sleep quality, nitric oxide bioavailability, free radical production, oxidative stress and inflammation. We hypothesize that 6 weeks of the NightWare intervention will improve outcomes of vascular aging (e.g., large elastic arterial stiffening, vascular endothelial dysfunction) and autonomic function (cBRS, HRV) in adults with PTSD-related nightmares. The results from this pilot investigation will provide the basis for a larger randomized clinical trial that would be conducted to establish the efficacy of NightWare as a safe and effective therapeutic strategy for treating nightmares, promoting healthy vascular aging, autonomic function and reducing the risk for CVD later in life in adults with nightmares associated with PTSD.
项目总结/文摘

项目成果

期刊论文数量(0)
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Kerrie Moreau其他文献

Kerrie Moreau的其他文献

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{{ truncateString('Kerrie Moreau', 18)}}的其他基金

MitoQ supplementation for restoring aerobic exercise training effects on endothelial function in postmenopausal women
补充 MitoQ 恢复有氧运动训练对绝经后女性内皮功能的影响
  • 批准号:
    10686453
  • 财政年份:
    2022
  • 资助金额:
    $ 19.44万
  • 项目类别:
NightWare Therapeutic Platform for improving Cardiovascular Health inAdults With Nightmares Associated with PTSD
NightWare 治疗平台可改善患有 PTSD 相关噩梦的成年人的心血管健康
  • 批准号:
    10351054
  • 财政年份:
    2022
  • 资助金额:
    $ 19.44万
  • 项目类别:
Cardiovascular Consequences of Hypogonadism in Men
男性性腺功能减退症的心血管后果
  • 批准号:
    9206973
  • 财政年份:
    2016
  • 资助金额:
    $ 19.44万
  • 项目类别:
Biological Mechanisms of Vascular Dysfunction with Age and Estrogen Deficiency
年龄和雌激素缺乏导致血管功能障碍的生物学机制
  • 批准号:
    8732808
  • 财政年份:
    2013
  • 资助金额:
    $ 19.44万
  • 项目类别:
Cardiometabolic Consequences of the Loss of Ovarian Function
卵巢功能丧失的心脏代谢后果
  • 批准号:
    10712609
  • 财政年份:
    2012
  • 资助金额:
    $ 19.44万
  • 项目类别:
BIOLOGICAL MECHANISMS OF ARTERIAL STIFFENING WITH AGE AND ESTROGEN
年龄和雌激素导致动脉硬化的生物学机制
  • 批准号:
    7719538
  • 财政年份:
    2008
  • 资助金额:
    $ 19.44万
  • 项目类别:
SEX HORMONE REGULATION OF LARGE ARTERY STIFFNESS IN MEN
性激素对男性大动脉僵硬的调节
  • 批准号:
    7719481
  • 财政年份:
    2008
  • 资助金额:
    $ 19.44万
  • 项目类别:
HRT AND EXERCISE EFFECTS ON CENTRAL ARTERIAL COMPLIANCE
激素替代疗法和运动对中央动脉顺应性的影响
  • 批准号:
    7719504
  • 财政年份:
    2008
  • 资助金额:
    $ 19.44万
  • 项目类别:
HRT AND EXERCISE EFFECTS ON CENTRAL ARTERIAL COMPLIANCE
激素替代疗法和运动对中央动脉顺应性的影响
  • 批准号:
    7719544
  • 财政年份:
    2008
  • 资助金额:
    $ 19.44万
  • 项目类别:
HRT AND EXERCISE EFFECTS ON CENTRAL ARTERIAL COMPLIANCE
激素替代疗法和运动对中央动脉顺应性的影响
  • 批准号:
    7604454
  • 财政年份:
    2007
  • 资助金额:
    $ 19.44万
  • 项目类别:

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