200kV Cyro-Transmission Electron Microscope

学院间研究网络SRF AMICA（斯图加特研究中心先进材料创新和表征）汇集了斯图加特大学各种科学家的仪器，方法和技术专业知识，并加强了不同研究领域科学家之间的合作。计划中的透射电子显微镜将作为一种多用户仪器在非洲显微镜研究所核心设施的框架内操作，因此将提供给该大学的所有用户。它将替换一台无法修复的缺陷和三台过时的透射电子显微镜。这将在一个联合研究中心汇集透射电子显微镜领域的进一步专业知识。通过透射电子显微镜对光束敏感材料进行高分辨率表征是当前生物学、生物医学、化学和材料科学研究领域必不可少的技术。为了充分表征光束敏感样品（特别是使用冷冻和断层扫描方法），目前斯图加特大学没有合适的设备可用-尽管存在需求-特别是在用户模式下的广泛应用。Cryo-sTEM的应用旨在满足这一需求，并确保通过AMICA轻松访问该方法。这里所选择的仪器配置符合各种不同参与研究小组的要求。计划中的Cryo-sTEM将研究的当前和计划中的研究项目的光束敏感材料包括生物材料、生物矿物、病毒、DNA/RNA纳米结构、哺乳动物细胞、肌肉组织、聚合物、水凝胶、塑料和混合材料。研究问题和项目范围从生物学、生物医学到化学、材料科学以及一些跨学科和跨学院的研究项目。

The interfaculty research network SRF AMICA (Stuttgart Research Focus Advanced Materials Innovation and Characterization) pools the instrumental, methodological and technical expertise of various scientists at the University of Stuttgart and strengthens the collaboration between scientists of different research areas. The planned transmission electron microscope will be operated as a multi-user instrument within the framework of the AMICA core facility and will thus be available to all users of the university. It will replace one irreparably defective and three outdated transmission electron microscopes. This will bring together further expertise in the field of transmission electron microscopy in a joint research center. High-resolution characterizations of beam-sensitive materials by transmission electron microscopy are essential and state of the art for current research areas in biology, biomedicine, chemistry and materials science. For the adequate characterization of beam-sensitive samples (especially with cryo- and tomography methods), there is currently no suitable equipment available at the University of Stuttgart - despite the existing need - especially not for the broad application in user mode. The application for the Cryo-sTEM is intended to meet this need and to ensure easy access to the method via AMICA. The selected instrument configuration requested here meets the requirements for a variety of different participating research groups. Beam-sensitive materials of current and planned research projects to be investigated with the planned Cryo-sTEM include biogenic materials, biominerals, viruses, DNA/RNA nanostructures, mammalian cells, muscle tissue, polymers, hydrogels, plastics and hybrid materials. The research questions and projects range from biology and biomedicine to chemistry, materials science and a number of interdisciplinary and cross-faculty research projects.