Study of Vestibulo-Autonomic Responses to Centrifugal Acceleration

前庭自主神经对离心加速度反应的研究

• 批准号: 60570059
• 负责人: WATANABE SATORU
• 金额: $ 1.09万
• 依托单位: Research Institute of Environmental Medicine, Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570059/
• 关键词: 遠心加速度; 前庭神経系; 呼吸; 心機能; 心拍出量

The aim of this study is to clarify how the vestibular apparatus does effect on the cardio-pulmonary functions. A relatively long period exposure (10 min) to centrifugal acceleration force were generated by a centrifuge, which has a horizontal arm length of 1.5 m, and produces up to 15 g by means of computer. In order to compare the vestibular influences, the animals used were divided into two groups, one with intact hamsters (IH), and the other with bilateral labyrinthectomized ones (LTH). Both animals were loaded by the acceleration from each one of 3 directions, -X (from back to abdomen), +Z (from head to tail) and -Z (from tail to head). Each direction of loading acceleration revealed different influences. The most effective change of cardiac function was caused by +Z acceleration (+Gz). Exposure of +2Gz caused only slight decrease of the heart rate and cardiac output, but a half of animals exposed +4Gz suffered a fatal damage, which was shown the atrio-venticular block by the ECG. No difference between IH and LTH was found by +Gz loading. While -Z acceleration (-Gz) were not serious up to 10 g, but the heart rate, the cardiac output, and minute volume of respiration were decreased in pallarel to the magnitude of acceleration. Those decreases were larger in LTH than in IH. This fact implies that the vestibular organ may send some defensive reflex signals to cardio-pulmonary organs through the autonomic nervous system.

本研究旨在探讨前庭器官对心肺功能的影响。一个相对较长的时间（10分钟）暴露于离心加速力产生的离心机，它具有1.5米的水平臂长，并产生高达15 g的计算机。为了比较前庭的影响，所用的动物被分为两组，一组是完整的仓鼠（IH），另一组是双侧前庭切除的仓鼠（LTH）。两只动物均通过3个方向（-X（从背部到腹部）、+Z（从头到尾）和-Z（从尾到头））的加速度加载。加载加速度的不同方向对应力场的影响不同。+Z加速度（+Gz）引起的心功能变化最大。+2Gz暴露仅引起心率和心输出量的轻微下降，而+4Gz暴露的半数动物出现致命性损伤，心电图表现为房室传导阻滞。+Gz加载时IH和LTH无明显差异。而-Z加速度（-Gz）在10 g以下不严重，但心率、心输出量和每分钟呼吸量均随加速度的增加而降低。LTH组的下降幅度大于IH组。提示前庭器官可能通过自主神经系统向心肺器官发出防御性反射信号。

项目成果

H.Jijiwa: Proceedings of 1986 International Symposium on Biological Sciences in Space. (1987)

H.Jijiwa：1986 年空间生物科学国际研讨会论文集。

H.Satake: Proceedings of The fifteenth International Symposium on Space Technology and Science. 2073-2078 (1986)

H.Satake：第十五届国际空间技术与科学研讨会论文集。

H.Satake: J.J.Aerospace Environ.Med.22. 53-64 (1985)

H.Satake：J.J.Aerospace Environ.Med.22。

H.Satake: Sensorymotor Function under Weightlessness and Space Motion Sickness(Proceedings of the International Symposium on Space Medicine,Nagoya 1984). 99-110 (1985)

H.Satake：失重和太空晕动病下的感觉运动功能（国际太空医学研讨会论文集，名古屋 1984 年）。

Y.Mizuno: Proceedings of The fourteenth International Symposium on Space Technology and Science. 1559-1564 (1984)

Y.Mizuno：第十四届空间技术与科学国际研讨会论文集。