The role of sympathetic nervous system in regulation of gastric acid secretion.
交感神经系统在调节胃酸分泌中的作用。
基本信息
- 批准号:60570092
- 负责人:
- 金额:$ 0.96万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1985
- 资助国家:日本
- 起止时间:1985 至 1986
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1. In the urethane-anesthetized rats, electrical stimulation of the splanchnic nerve, gastric sympathetic nerve, reduced histamine-stimulated gastric acid secretion and mucosal blood flow (MBF). This inhibition of acid secretion and MBF was abolished by phentolamine, an alpha-adrenoceptor blocking agent, but not by propranolol, a beta-adrenoceptor blocking agent.2. In urethane-anesthetized rats, increased release of histamine and 1-methyl histamine, a metabolite of histamine, into gastric juice and portal vein was not observed during infusion of bethanechol, a cholinergic muscarinic receptor agonist, or pentagastrin. Furthermore, in in vitro experiment with perfusion of gastric mucosa, these agents also could not increase the release of histamine and its metabolite.Previously, we showed that electrical stimulation of the splanchnic nerve reduced the bethanechol- and pentagastrin-induced gastric acid secretion without reduction of MBF, through alpha-1 adrenoceptor-mediated mechanisms. On the other hand, inhibition of histamine-induced acid secretion by stimulation of the splanchnic nerve, in the present study, was secondary to a reduction of MBF. Thus, a possibility that alpha-1 adrenoceptors located on the histamine-containing cells reduce the release of histamine was raised. But, in the present experiment, the release of histamine was not enhanced by bethanechol or pentagastrin. From these results, it is suggested that alpha-1 adrenoceptors locate on parietal cells, thereby reducing bethanechol- and pentagastrin-induced acid secretion in rats.
1. 经氨基脲麻醉的大鼠,电刺激内脏神经、胃交感神经后,组胺刺激的胃酸分泌和粘膜血流量(MBF)减少。这种酸分泌和MBF的抑制作用被酚妥拉明(一种α -肾上腺素受体阻滞剂)所消除,但不被心得安(一种β -肾上腺素受体阻滞剂)所消除。在氨基脲麻醉的大鼠中,在输注乙二酚(胆碱能毒蕈碱受体激动剂)或五胃泌素时,没有观察到组胺和组胺代谢产物1-甲基组胺释放到胃液和门静脉的增加。此外,在胃粘膜灌注的体外实验中,这些药物也不能增加组胺及其代谢物的释放。之前,我们通过α -1肾上腺素受体介导的机制表明,电刺激内脏神经可减少亚丁醇和戊胃泌素诱导的胃酸分泌,但不减少MBF。另一方面,在本研究中,通过刺激内脏神经抑制组胺诱导的酸分泌是MBF减少的继发性作用。因此,位于含组胺细胞上的α -1肾上腺素受体减少组胺释放的可能性被提出。但是,在本实验中,乙二酚和五味子碱对组胺的释放没有促进作用。从这些结果可以看出,α -1肾上腺素受体位于壁细胞上,从而减少了甲萘酚和pentagastrin诱导的大鼠酸分泌。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kunihiko Yokotani,Yoshitsugu Osumi: The Journal of Pharmacology and Experimental Therapeutics. 236. 770-775 (1986)
横谷邦彦,大隅良嗣:药理学和实验治疗学杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Kunihiko Yokotani and Yoshitsugu Osumi: "Lack of direct splanchnic nerve inhibitory effects on histamine-induced gastric acid secretion in rats" The Journal of Pharmacology and Experimental Therapeutics. 236. 770-775 (1986)
Kunihiko Yokotani 和 Yoshitsugu Osumi:“对组胺诱导的大鼠胃酸分泌缺乏直接内脏神经抑制作用”《药理学和实验治疗学杂志》。
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YOKOTANI Kunihiko其他文献
YOKOTANI Kunihiko的其他文献
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{{ truncateString('YOKOTANI Kunihiko', 18)}}的其他基金
Roles of endocannabinoid in the modulation of central sympatho-adrenomedullary outflow in rat
内源性大麻素在大鼠中枢交感肾上腺髓质流出调节中的作用
- 批准号:
20590702 - 财政年份:2008
- 资助金额:
$ 0.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Roles of brain nitric oxide and prostaglandins in the regulation of central sympatho-adrenomedullary outflow in rats
脑一氧化氮和前列腺素在大鼠中枢交感肾上腺髓质流出调节中的作用
- 批准号:
08672614 - 财政年份:1996
- 资助金额:
$ 0.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Releasing mechanisms of acetylcholine from an isolated rat stomach
离体大鼠胃中乙酰胆碱的释放机制
- 批准号:
04671416 - 财政年份:1992
- 资助金额:
$ 0.96万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
PROSTAGLANDIN ACTIVITY AND CONTROL OF GASTRIC MUCOSAL BLOOD FLOW
前列腺素活性和胃粘膜血流控制
- 批准号:
4689064 - 财政年份:
- 资助金额:
$ 0.96万 - 项目类别: