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Roles of endocannabinoid in the modulation of central sympatho-adrenomedullary outflow in rat

Roles of endocannabinoid in the modulation of central sympatho-adrenomedullary outflow in rat
内源性大麻素在大鼠中枢交感肾上腺髓质流出调节中的作用
批准号:
20590702
负责人:
YOKOTANI Kunihiko
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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英文摘要
We tried to clarify the role of monoacylglycerol (MAG) involved in the central activation of sympatho-adrenomedullary (S-A) outflow by intracerebroventricular administration of stress-related peptides (CRF, vasopressin, bombesin) using anesthetized rats. Elevation of plasma catecholamines evoked by these peptides is mediated by arachidonic acid cascade produced by phospholipase C/diacylglycerol lipase/MAG lipase-mediated mechanisms. In addition, MAG (=2-arachidonoylglycerol: the most powerful endocannabinoid) reduced these peptide-induced activation of S-A outflow through CB1 receptor-mediated mechanisms in rats.
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Endogenously generated 2-AG plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats
内源性产生的 2-AG 在铃蟾肽诱导的大鼠中枢肾上腺髓质流出物激活中发挥抑制作用
DOI: --
发表时间: 2011
期刊: Eur J Pharmacol
影响因子: 5
作者: [Shimizu T, Lu L, Yokotani K]
通讯作者: Yokotani K
脳室内投与したNMDAによる副腎髄質形賦活機構の薬理学的解析
侧脑室注射NMDA激活肾上腺髓质机制的药理学分析
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [岡田尚志郎, 山口奈緒子, 清水孝洋, 横谷邦彦]
通讯作者: 横谷邦彦
Endogenously generated 2-AG plays an inhibitory role in bombesin- induced activation of central adrenomedullary outflow in rats.
内源性产生的 2-AG 在铃蟾肽诱导的大鼠中枢肾上腺髓质流出物激活中发挥抑制作用。
DOI: --
发表时间: 2011
期刊: Eur.J.Pharmacol. (in press)
影响因子: --
作者: [Shimizu T, Lu L, Yokotani K.]
通讯作者: Yokotani K.
Brain a4β2 nicotinic acetylcholine receptors are involved in the secretion of noradrenaline and adrenaline from adrenal medulla in rats.
大脑a4β2烟碱乙酰胆碱受体参与大鼠肾上腺髓质去甲肾上腺素和肾上腺素的分泌。
DOI: --
发表时间: 2011
期刊: Eur. J. Pharmacol. 654
影响因子: --
作者: [Shimizu T, Tanaka K, Hasegawa T, Yokotani K.]
通讯作者: Yokotani K.
26
    Roles of brain nitric oxide and prostaglandins in the regulation of central sympatho-adrenomedullary outflow in rats
    • 批准号:
      08672614
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.34万
    • 财政年份:
      1996
    • 负责人:
      YOKOTANI Kunihiko
    • 依托单位:
    Releasing mechanisms of acetylcholine from an isolated rat stomach
    • 批准号:
      04671416
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1992
    • 负责人:
      YOKOTANI Kunihiko
    • 依托单位:
    The role of sympathetic nervous system in regulation of gastric acid secretion.
    • 批准号:
      60570092
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $0.96万
    • 财政年份:
      1985
    • 负责人:
      YOKOTANI Kunihiko
    • 依托单位:
    海外基金