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Sex Difference of Free Erythrocyte Protoporphyrin (FEP) in Humans and Rats

人和大鼠游离红细胞原卟啉（FEP）的性别差异

基本信息

批准号：
60570244
负责人：
MIURA Hajime
金额：
$ 1.15万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570244/
关键词：
Blood Lead FEP ALA-D Urinary ALA Urinary CP Sex Difference Serum Iron 貧血指標

项目摘要

Several biological parameters of lead exposure and iron deficiency anemia, such as FEP, <delta> -aminolevulinic acid dehydratase (ALA-D), Serum iron (FeS), Ht, Hb etc, were measured for 98 women and 59 men (both 51 <-!+> 11 years old) lived in rural districts.Women showed a higher FEP level than men; 63.0 <-!+> 19.4 in women and 54.6 <-!+> 21.2 <mu> g/dl・pcv in men. Women Pb-B level showed a lower tendency than in men. Ht, Hb and FeS were also lower in women than in men. There was no difference in ALA-D activity between both sexes.Correlations between these biological parameters were calculated, and no significant correlations were observed between Pb-B and these parameters. There were a little correlations between Ht, Hb and FEP for FeS.In rats injected lead (0.5 mg Pb/kg・BWX6) and the control, FEP level was lower in female than in male, and the same pattern was observed in urinary <delta> -aminolevulinic acid (ALA-U). In high lead dose group (5 mg Pb/kg.BWX6), urinary coproporphyrin (CP-U) was lower in female than in male.In another study with castrated male rats, estradiol (50, 250 <mu> g/kg・BWX22) was injected into the rats with or without lead (5 mg Pb/kg.BWX6). No significant increase due to estradiol was observed in FEP, ALA-U and CP-U in both rats with or without lead, while a decrease in Ht and body weight by estradiol was shown.These results suggest that the increase of FEP in human females is not caused by sex hormone, and mainly caused by tendency of iron deficiency anemia induced by blood loss (i.e. menses, pregnancy, delivery etc) and the differences of dietary habits (quality and quantity of food etc).

对<delta>98名女性和59名男性（均为51 <-！+>）进行了血铁（FeS）、血红蛋白（Hb）、血清β-氨基乙酰丙酸脱氢酶（ALA-D）、FEP、Ht、Hb等与铅接触和缺铁性贫血有关的生物学指标的测定。11岁）生活在农村地区。女性的FEP水平高于男性，63.0 <-！+> 19.4女性和54.6 <-！+> 21.2 g<mu>/dl·pcv。女性铅-硼水平有低于男性的趋势。女性的Ht、Hb和FeS也低于男性。ALA-D活性无性别差异，并计算了这些生物学参数之间的相关性，Pb-B与这些参数之间无显著相关性。在染铅（0.5mgPb/kg·BWX 6）组和对照组中，雌性大鼠的FEP水平低于雄性大鼠，尿<delta>-氨基乙酰丙酸（ALA-U）水平也低于雄性大鼠。高铅组（5 mg Pb/kg·BWX 6）雌性大鼠尿粪卟啉（CP-U）低于雄性大鼠，去势雄性大鼠分别注射雌二醇（50、250 <mu>g/kg·BWX 22）和雌二醇（50、250 g/kg·BWX 22）。雌激素对染铅和不染铅大鼠的FEP、ALA-U和CP-U无明显影响，但对Ht和体重有明显影响，提示雌性大鼠FEP的升高不是性激素引起的，而主要是失血引起的缺铁性贫血倾向所致（即月经、怀孕、分娩等）和饮食习惯的差异（食物的质量和数量等）。