The role of feed back system from peripferal arterial pressure senser to hypothalamus in the development of hypertension

周围动脉压力传感器到下丘脑的反馈系统在高血压发生中的作用

• 批准号: 60570402
• 负责人: TAKEDA Kazuo
• 金额: $ 1.02万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570402/
• 关键词: Blood pressure; Renal nerves; Sympathetic nerve system; Hypothalamus; Baroreflex; Cardiopulmonary refelx; DOCA; salt hypertension; SHR

This study was planned to determine the feed back relationship between the hypothalamo -sympathetic nerve sytem and pressure sensitive systems of vessels and kidneys.(1)Kidney and Hypothalamus. Pressor and incresed sympathetic nerve responses to posterior hypothalamic stimulations were attenuated by renal denervations in normotensive rats. Renal denervation attenuated the development of hypertension in DOCA/salt treated rats and SHR, with the inhibition of hypothalamic hyperactivity. These findings suggest that kidney regulate hypothalamic sensitivity via renal nerves and play some role in the development of hypertension.(2)Baroreflex and Hypothalamus. Sinoaortic denervation (SAD) could not alter the development of hypertenion in DOCA/salt hypertensive rats. Hypothalamic hypersentivity did not modified by SAD in DOCA/salt treated rats. Cardiovascular and sympatho-inhibitory responses to aortic depressr nerve (ADN) stimulations were attenuated in the hypertesnive and pre-hypertensive stage of DOCA/salt hypertensive rats, while responses to hypothalamic stimulations were augmented. These findings suggest that baroreflex may be attenuated before the development of hypertension and contribute to the development of hypertension and hypothalamic hyperactivity.(3)Cardiopulmonary reflex and Hypothalamus. Cardiovascular and sympathetic nerve responses to hypothalamic stimulations were not changed by vagus cut which includes the afferent fibers from cardiopulmonary receptors.Taken together all findings, hypothalamus receives the importnat informations from the kidney and baroreceptors to regulate cardiovascular system. In hypertension, this feed back system may be altered and contribute to the development of hypertension.

本研究旨在确定下丘脑-交感神经系统与血管和肾脏压力敏感系统之间的反馈关系。(1)肾脏和下丘脑。血压正常的大鼠中，肾去神经支配可减弱交感神经对下丘脑后部刺激的升压和增强反应。 DOCA/盐处理的大鼠和 SHR 中去肾神经减轻了高血压的发展，并抑制了下丘脑的过度活跃。这些结果提示肾脏通过肾神经调节下丘脑的敏感性，在高血压的发生发展中发挥一定作用。(2)压力反射与下丘脑。主动脉去神经术（SAD）不能改变DOCA/盐高血压大鼠高血压的发展。在 DOCA/盐治疗的大鼠中，SAD 并未改变下丘脑超敏反应。在 DOCA/盐高血压大鼠的高血压和高血压前期阶段，对主动脉降压神经 (ADN) 刺激的心血管和交感抑制反应减弱，而对下丘脑刺激的反应增强。这些结果表明，压力感受反射可能在高血压发生之前减弱，并导致高血压和下丘脑过度活跃的发生。(3)心肺反射和下丘脑。心血管和交感神经对下丘脑刺激的反应不会因迷走神经切断而改变，迷走神经包括来自心肺受体的传入纤维。综合所有发现，下丘脑从肾脏和压力感受器接收重要信息来调节心血管系统。在高血压中，这种反馈系统可能会改变并导致高血压的发展。

项目成果

Yutaka Nakamura;Kazuo Takeda: HYPERTENSION.

中村丰；武田一夫：高血压。

Yutaka Nakamura: Hypertension.

中村丰：高血压。

Kazuo Takeda: Journal of Hypertension.

武田一夫：高血压杂志。

Shingo Kawasaki, Kazuo Takeda, et al.: "Increased extracellular concetration of norepinephrine in the hypothamus by sinoaortic denervation." American Journal of Hypertesnion. (1988)

Shingo Kawasaki、Kazuo Takeda 等人：“通过去窦主动脉神经术增加下丘脑中去甲肾上腺素的细胞外浓度。”

Kazuo Takeda: American Journal of Physiology.

武田一夫：美国生理学杂志。