Development of the artificial bone for diagnosis

计算机断层扫描是一种无创评估骨矿物质含量的方法。该方法需要标定体模。本研究将制备的多核微胶囊或无机壁微胶囊（和-型）经压缩成型（20 t/cm ^2）制成校准骨模型<I><II>。多核微胶囊是含有许多二氧化钛颗粒（金红石型，直径：0.3 μ m）的直径为0.5-2.0 mm的明胶球<micro>。<I>通过在室温下用自动陶瓷研钵和搅拌器将二氧化钛颗粒和尼龙12微球（直径：5.0 μ m）共混60分钟来制备-型无机壁微胶囊<micro>。<II>型无机壁微胶囊的制备。在冲击压力的作用下，二氧化钛颗粒进入尼龙12微球表面，形成由无机化合物（壁材）和有机化合物（芯材）组成的微胶囊。无机化合物与有机化合物的比例可以通过改变两种化合物的混合比例来任意控制。在这项研究中开发的材料使得有可能制备具有任意CT值的骨模型。所获得的骨模型在X射线吸收方面非常均匀，似乎对评价骨矿物质含量非常有用。

Computed tomography is a method for noninvasive assessment of bone mineral content. This method needs calibration phantoms. In this study, the calibration bone phantoms were made by the compression molding(20 t/ <cm^2> ) of multicore microcapsules or inorganic wall microcapsules( <I> and <II> -types) prepared. The multicore microcapsules were gelatin spheres of 0.5-2.0 mm diameters containing many titanium dioxide particles(rutile type, diameter: 0.3 <micro> m). <I> -type inorganic wall microcapsules were prepared by blending the titanium dioxide particles and nylon 12 microspheres(diameter: 5.0 <micro> m) at room temperature for 60 min with an automatic ceramic mortar and stirrer. <II> -type inorganic wall microcapsules were prepared by an impact type hybridization machine. The impacting pressure drives the titanium dioxide particles into nylon 12 microsphere surfaces and the resulting microcapsules are made up of inorganic compound(wall material) and organic compound(core material). The ratio of the inorganic compound to the organic compound can be arbitrarily controlled by changing the mixing ratio of both compounds. The materials developed in this study make possible to prepare the bone phantoms having arbitrary CT-values. The bone phantoms obtained were extremely homogeneous in regard to X-ray absorption and seemed very useful for evaluation the bone mineral content.