Nanoengineered hybrid coatings that control inflammation to artificial bone

控制人造骨炎症的纳米工程混合涂层

• 批准号: DP240103271
• 负责人: Prof Peter Kingshott
• 金额: $ 39.39万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240103271
• 关键词: Nanoengineered; hybrid; coatings; control; inflammation

This project aims to develop novel biocompatible surfaces using nanotechnology approaches to understand how cells attach to and grow on artificial bone materials. This research is significant because it combines novel nanofabrication and surface modification strategies for unprecedented control and manipulation of inflammatory cell behaviour relevant to orthopaedic implants. The project will overcome current limitations of uncontrollable inflammatory reactions to surfaces. The multifunctional surfaces are expected to give the biomaterials field new tools to control and maintain bone cell functionality, in vitro. Potential long-term benefits include applications as coatings in tissue engineering, regenerative medicine, and medical implants.

该项目旨在利用纳米技术方法开发新的生物兼容表面，以了解细胞如何附着在人造骨材料上并在其上生长。这项研究意义重大，因为它结合了新的纳米制造和表面修饰策略，以前所未有的方式控制和操纵与骨科植入物相关的炎症细胞行为。该项目将克服目前对表面无法控制的炎症反应的限制。多功能表面有望为生物材料领域提供新的工具，在体外控制和保持骨细胞的功能。潜在的长期益处包括在组织工程、再生医学和医疗植入物中作为涂层的应用。