Experimental and Clinical Study for Atrial Natriuretic Hormone and Hemodynamics on Surgical Stress

To clarify the pathophysiological role and phamacological effect of atrial natriuretic polypeptide(ANP)on surgical stress，we investigated the plasma ANP levels following the operation and the ANP‘s effect on oliguric models induced by norepinephrine.(1)Plasama ANP levels following surgical stress。Blood samples were obtained from esophageal cancer patients before and after operations。Moreover，various parameters of hemodynamics were measured by Swan-Ganzcatheter.The plasma ANP levels were under40pg/ml before operations。Tese were elevated significantly by student‘s t test up to62 18(M SD)，59 24 50 13，51 15 pg/ml on1，2，3，4 postoperatinve day，respectively.Vasopressine and aldostelon showed their peaks on1，2postoperative day，respectively.The plasma ANP levels were not coresponded to CVP and PWP.(2)Phamocological effect of ANP on surgical stress We investigated the effect of ANP on a oliguria and peripheral circulatory collapse induced by a hypersecretion of cathecolamine。After the constant infusion of norepinephirine(4/kg·min)for 20min，-hANP(1/kg·min)or Dopamin(3/kg·min)was administrated by constant infusion for 20min。Urine outputs decreased by the administration of norepinephrine were increased more than4times by ANP.On the other hand，these effect was not observed by dopamin。

To clarify the pathophysiological role and phamacological effect of atrial natriuretic polypeptide ( ANP ) on surgical stress, we investigated the plasma ANP levels following the operation and the ANP's effect on oliguric models induced by norepinephrine.( 1 ) Plasama ANP levels following surgical stress. Blood samples were obtained from esophageal cancer patients before and after operations. Moreover, various parameters of hemodynamics were measured by Swan-Ganzcatheter. The plasma ANP levels were under 40 pg/ml before operations. Tese were elevated significantly by student's t test up to 62 18(M SD), 59 24 50 13, 51 15 pg/ml on 1, 2, 3, 4 postoperatinve day, respectively. Vasopressine and aldostelon showed their peaks on 1, 2 postoperative day, respectively. The plasma ANP levels were not coresponded to CVP and PWP.( 2 ) Phamocological effect of ANP on surgical stress We investigated the effect of ANP on a oliguria and peripheral circulatory collapse induced by a hypersecretion of cathecolamine. After the constant infusion of norepinephirine ( 4 /kg・min ) for 20 min, -hANP ( 1 /kg・min ) or Dopamin ( 3 /kg・min ) was administrated by constant infusion for 20 min. Urine outputs decreased by the administration of norepinephrine were increased more than 4 times by ANP. On the other hand, these effect was not observed by dopamin.