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Experimental and Clinical Study for Atrial Natriuretic Hormone and Hemodynamics on Surgical Stress

心房钠尿激素和血流动力学对手术应激的实验和临床研究

基本信息

批准号：
60570601
负责人：
AIKAWA Naoki
金额：
$ 1.15万
依托单位：
Department of Surgery, School of Medicine,Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570601/
关键词：
Surgical stress Atrial Natriuretic Hormone Dopamine Diuresis Norepinephrine ドーパミン利尿

项目摘要

To clarify the pathophysiological role and phamacological effect of atrial natriuretic polypeptide ( ANP ) on surgical stress, we investigated the plasma ANP levels following the operation and the ANP's effect on oliguric models induced by norepinephrine.( 1 ) Plasama ANP levels following surgical stress. Blood samples were obtained from esophageal cancer patients before and after operations. Moreover, various parameters of hemodynamics were measured by Swan-Ganzcatheter. The plasma ANP levels were under 40 pg/ml before operations. Tese were elevated significantly by student's t test up to 62 18(M SD), 59 24 50 13, 51 15 pg/ml on 1, 2, 3, 4 postoperatinve day, respectively. Vasopressine and aldostelon showed their peaks on 1, 2 postoperative day, respectively. The plasma ANP levels were not coresponded to CVP and PWP.( 2 ) Phamocological effect of ANP on surgical stress We investigated the effect of ANP on a oliguria and peripheral circulatory collapse induced by a hypersecretion of cathecolamine. After the constant infusion of norepinephirine ( 4 /kg・min ) for 20 min, -hANP ( 1 /kg・min ) or Dopamin ( 3 /kg・min ) was administrated by constant infusion for 20 min. Urine outputs decreased by the administration of norepinephrine were increased more than 4 times by ANP. On the other hand, these effect was not observed by dopamin.

为了阐明心房钠尿肽(ANP)对手术应激的病理生理作用和药理学作用，我们研究了手术应激后血浆ANP水平以及ANP对去甲肾上腺素诱导的少尿模型的影响。(1)手术应激后血浆ANP水平。从食道癌患者手术前后采集血样。此外，通过Swan-Ganzcatheter测量血流动力学的各种参数。术前血浆ANP水平低于40 pg/ml。通过学生 t 检验，Tese 在术后第 1、2、3、4 天分别显着升高至 62·18(MSD)、59·24·50·13、51·15 pg/ml。加压素和醛固酮分别在术后 1、2 天达到峰值。血浆ANP水平与CVP和PWP不对应。(2)ANP对手术应激的药理学作用我们研究了ANP对儿茶酚胺分泌过多引起的少尿和外周循环衰竭的影响。去甲肾上腺素（4/kg·min）持续输注20分钟后，持续输注-hANP（1/kg·min）或多巴明（3/kg·min）20分钟。因服用去甲肾上腺素而减少的尿量，因服用ANP而增加了4倍以上。另一方面，多巴胺没有观察到这些效果。