The Protective Effect of Perfluorochemicals (Fluosol-43) for the Spinal Cord in Ischemic Condition

全氟化合物 (Fluosol-43) 对缺血状态下脊髓的保护作用

• 批准号: 60570702
• 负责人: SIMIZU Toyonobu
• 金额: $ 1.15万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570702/
• 关键词: Perfluorochemicals; Fluosol-43; Evoked Spinal cord Potentials; 脊髄保護効果; fluorocarbon・emulsion

However the monitoring of evoked spinal cord potentials (ESP) is getting popular to avoid the spinal cord injury due to ischemia in the surgery, no administration has been discovered for protection of spinal cord yet. Our attention has been drawn to the so-called artificial blood substitute, perfluorochemicals (FC), which consists of a small particle less than 0.1 micron, and has a high oxygen-carrying capacity.Experiments were performed on adult dogs. Following laminectomies at Th 11-12 level under general anesthesia, evoked spinal cord potentials were recorded from bipolar electrodes in the midline dorsal epidural space at Th9 level by stimulation of lower spinal cord (L5).The cord ischemia was made by inflation of a balloon catheter which was inserted from right femoral artery into the upper thoracic aorta.As a control study, the changes of ESP were observed continuously until the amplitude of ESP decreased to 70 percents of normal level. After the potential was recovered nomally, 30 percents of whole blood was exchanged for FC. The spinal cord ischemia started again and the changes of ESP were compaired with control.For the result, in 50 percents cases, it could be prevented to decreased of amplitude of ESP by FC infusion under condition of cord ischemia.

然而，脊髓诱发电位（ESP）的监测越来越普遍，以避免在手术中由于缺血引起的脊髓损伤，尚未发现脊髓保护的管理。我们的注意力已经被吸引到所谓的人工血液替代品，全氟化合物（FC），它由小于0.1微米的小颗粒组成，具有高携氧能力。在全麻下行Th11 - 12节段椎板切除术后，刺激下脊髓（L5），在Th9节段硬膜外腔中线背侧记录脊髓诱发电位，并将球囊导管从右股动脉插入上胸主动脉，造成脊髓缺血。持续观察ESP的变化，直至ESP波幅降至正常值的70倍。待电位恢复正常后，用30毫升全血置换FC。结果：50例脊髓缺血再灌注患者，在脊髓缺血状态下，FC灌注可阻止ESP波幅的降低。