The pathogenesis of rapidly destructive coxopathy

本项目旨在研究快速破坏性髋关节病（RDC）的发病机制。组织学研究表明，RDC可能是老年人股骨头缺血性坏死的一种特殊类型。股骨头缺血性坏死，但是，不能解释的过程中破坏髋臼侧的发病机制。为了阐明髋臼破坏的病理机制，我们用酶标抗体法检测了RDC髋关节免疫功能紊乱的可能性，结果发现RDC股骨头上有大量的IgB沉积，其形态与RA相似。

This project aimed to investigate the pathogenesis of rapidly destructive coxopathy (RDC). Histological studies on the femoral head with RDC have revealed that it might be a special pattern of avascular necrosis of the femoral head occurring in the old aged. Avascular necrosis of the femoral head, however, cannot explain the pathogenesis of the process destroying the acetabular side. In order to clear up the pathomechanism of acetabular destruction, we have examined a possibility of being immunological disturbance in the hip joint with RDC using emnzymelabeled antibody method.From the results of the investigation, it has been revealtd that abundant deposition of IgB on the femoral head with RDC was observed and the pattern was very similar to that of RA.