The relationship between patterns of fetal breathing movements and the development of central nervous system

胎儿呼吸运动模式与中枢神经系统发育的关系

• 批准号: 60570766
• 负责人: HIGUCHI Motokazu
• 金额: $ 1.15万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570766/
• 关键词: Fetus; Fetal Maturation; Fetal Breathing Movements; Fetal Heart Rate; Central Nervous System; Amniotic Fluid; 羊水; 胎児神経系成熟度; 胎児心拍一過性頻脈; 胎動

The possibility of the assessment of functional maturation of human fetal lung was investigated in this study through the analysis of fetal breathing movements (FBM) by real time ultrasonic B-scanner. The relationship between the frequencies of the various durations of FBM and the age of gestation was studied in 15 normal pregnant women. The frequency of successive FMB with a duration of 【ltoreg】10 sec. decreased sigificantly from 25 to 32 weeks of gestation. The frequency of succssive FBM lasted for 【gtoreg】30 sec. showd a significant increase at the same age. An intimate correlation was demonstrated between the the freqency of FBM lasted for 10 【gtoreg】30 sec., the number of fetal heart rate accelerations per hour and the value of long term valiavility. These results suggest that a prolongation of the duration of successive FBM fo the fetus is related to the functional development of the central nervus system.The pattern of FBM classified into 3 types by the depth, irregularity and the duration of FBM in 72 pregnant women who eventually underwent preterm deliveries. The incidence of neonatal respiratory disturbances including RDS decreased sigificantly with a maturation of FBM pattern. From these results showed that the analysis of FBM could contibute to the prenatal evaluation of the functional maturity of human fetal lung.

本研究通过实时B超对胎儿呼吸运动的分析，探讨评价人胎肺功能成熟的可能性。本文研究了15例正常孕妇胎膜早破各时程的出现频率与孕龄的关系。持续时间为[ltoreg]10秒的连续FMB的频率。从妊娠25周到32周显著下降。连续的FBM频率持续30秒。在同一年龄段显示出显著的增长。胎心持续10~30秒的频率、每小时胎心加速次数与远期有效值密切相关。这些结果提示，胎儿连续胎膜持续时间的延长与中枢神经系统功能发育有关。72例早产孕妇的胎膜形态按胎膜深度、不规则程度和胎膜持续时间分为3型。随着FBM模式的成熟，包括RDS在内的新生儿呼吸障碍的发生率显著下降。结果表明，FbM分析可用于人胎肺功能成熟度的产前评估。

项目成果

樋口誠一: 日本産科婦人科学会雑誌. 38. 1218-1226 (1986)

Seiichi Higuchi：日本妇产科学会杂志 38. 1218-1226 (1986)。

Motokazu Higuchi: "The relationship of the duration of:fetal breathing movements at 25 to 32 weeks gestatin in normal pregnancy" Am. J. Obstet. Gynecol.

Motokazu Higuchi：“正常妊娠 25 至 32 周孕激素与胎儿呼吸运动持续时间的关系”Am。

樋口誠一,他: 産婦人科の実際. 32. 653-661 (1983)

Seiichi Higuchi 等人：妇产科实践 32. 653-661 (1983)。

樋口誠一: 日本産婦人科学会雑誌.

Seiichi Higuchi：日本妇产科学会杂志。

Motokazu Higuchi: Am.J.Obstet.Gynecol.

Motokazu Higuchi：Am.J.Obstet.Gynecol。