Histogenesis of Mixed Carcinoma of the Uterine Cervix

宫颈混合癌的组织发生

• 批准号: 60570771
• 负责人: TSUKAHARA Yoshiharu
• 金额: $ 0.45万
• 依托单位: YAMANASHI MEDICAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570771/
• 关键词: Uterine cervical cancer; Mixed carcinoma; 腺扁平上皮癌; 粘液扁平上皮癌

Mixed carcinoma of the uterine cervix is a rare tumor and its prognosis is poorer than that of sauamous cell carcinoma. The histologic criteria of this tumor and its histogenesis are not established and controversial.This study was performed to try to establish the histologic criteria and to clarify the histogenesis of this tumor.Materials and methods are as follows; 1) Cases; 5 cases of non-cancerous, 10 cases of early stage, 20 cases of advanced epidermoid carcinoma, one case of early stage and 10 cases of typical advanced mixed carcinoma. 2) Methods; Histochemical, enzyme histochemical, and electromicroscopic methods were used to investigate the morfologic nature of the epitelia.The results obtained were as follows; 1) Mixed carcinoma was classified into two subclasses; adenosquamous carcinoma and mucoepidermoid carcinoma and the prognosis of the former is less than the latter. 2) The characteristics of the epithelia of adenosquamous cell carcinoma were clear cytoplasm, positive with mucous reaction in the brush border, whereas the epithelia of mucoepidermoid carcinoma contained mucous vesicles and keratin. 3) Tumor cells of the mixed carcinoma showed bipotential nature of columnar epithelium and squamous epithelium, histochemically or electromicroscopically. 4) The original site of the early case of mixed carcinoma was the cleft portion between the surface epithelia and cervical glands. 5) From these results it may be considered that the histogenesis of mixed carcinoma is the cleft portion of cervical glands and that tumor cells possesses bipotential characteristics both squamous and columnar nature.

宫颈混合性癌是一种罕见的肿瘤，其预后较宫颈鳞癌差。该肿瘤的组织学标准及其组织发生尚未确定，且存在争议。本研究试图建立组织学标准，并阐明该肿瘤的组织发生。材料和方法如下：1)病例;无癌5例，早期10例，晚期表皮样癌20例，早期1例，典型晚期混合性癌10例。2)方法;采用组织化学、酶组织化学和电镜等方法观察上皮细胞的形态特征。所得结果如下：1)混合性癌分为两个亚类；腺鳞癌和黏液表皮样癌，前者预后较后者差。2)腺鳞状细胞癌的上皮特征为细胞质清晰，刷状边缘呈粘液反应阳性，而粘液表皮样癌的上皮则含有粘液囊泡和角蛋白。3)混合癌的肿瘤细胞在组织化学或电镜下表现为柱状上皮和鳞状上皮的双电位性质。4)早期混合性癌的原发部位为宫颈表面上皮与宫颈腺之间的间隙部分。5)从这些结果可以考虑，混合性癌的组织发生为宫颈腺裂部，肿瘤细胞具有鳞状和柱状的双电位特征。