Possible active components of Tan-Shen and Zi-Cao for ischemic heart disease

丹参和紫草治疗缺血性心脏病的可能活性成分

基本信息

  • 批准号:
    60571010
  • 负责人:
  • 金额:
    $ 0.45万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1985
  • 资助国家:
    日本
  • 起止时间:
    1985 至 1986
  • 项目状态:
    已结题

项目摘要

Extracts of Tan-shen(Salvia miltiorrhiza) and Zi-cao(Lithospermum erythrorhizon),Chinese traditional crude drugs, were reported to show activity for heart disease. Chemical examinations on these extracts were performed on the basis of the screening for hypoxic heart using isolated,perfused rat heart. The heart was subjected to hypoxic perfusion for 15 min,followed by 45 min-reoxygenation,and the recovery of cardiac contractile force and changes in UV absorbance of the perfusate were examined. Following compounds were isolated and identified: Tanshinone I,Tanshinone II,Dihydrotanshinone, Crypto-tanshinone from Salvia miltiorrhiza ; Acetylshikonin, <alpha> -Methyl n-butyrylshikonin,Shikonin from Lithospermum erythrorhizon. Among the compounds isolated Tanshinone I and Acetylshikonin elicited a significant recovery of the contractile force upon reoxygenation. Furthermore,depression of the increase in UV absorbance of the perfusate was also observed in hearts receiving Tanshinone I and Acetylshikonin. The results suggest that these substances are beneficial for the protection of myocardium from ischemia-induced derangements of myocardial function and metabloism.
丹参和紫草的提取物具有治疗心脏病的作用。在用离体灌流的大鼠心脏筛选缺氧心脏的基础上,对这些提取物进行化学检查。心脏进行缺氧灌注15分钟,然后45分钟复氧,心脏收缩力的恢复和灌流液的紫外吸光度的变化进行了检查。从丹参中分离鉴定了丹参酮I、丹参酮II、二氢丹参酮、隐丹参酮;从紫草中分离鉴定了乙酰紫草素、<alpha>-甲基正丁酰紫草素、紫草素。其中丹参酮I和乙酰紫草素引起了一个显着的恢复收缩力复氧。此外,在接受丹参酮I和乙酰紫草素的心脏中也观察到灌流液的UV吸光度增加的抑制。结果提示,这些物质对缺血引起的心肌功能和代谢紊乱具有保护作用。

项目成果

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