Cholinergic modulation of learning and learning related plasticity with event-related fMRI

事件相关功能磁共振成像对学习和学习相关可塑性的胆碱能调节

• 批准号: 5212686
• 负责人: Professorin Dr. Christiane M. Thiel
• 金额: --
• 依托单位: Abteilung Biologische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 1999
• 资助国家: 德国
• 起止时间: 1998-12-31 至 2001-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5212686?language=en
• 关键词: Cholinergic; modulation; learning; related; plasticity

The project aims to investigate the role of the neurotransmitter acetylcholine (ACh) in processes of learning and learning related plasticity in the human brain. A more general aim is to implement combined functional magnetic resonance imaging (fMRI) with pharmacological challenges in the context of cognitive tasks in humans. With such an approach the following questions will be addressed in a series of psycho-pharmacological experiments involving event-related fMRI: i) the role of ACh in learning related cortical plasticity ii) the cholinergic contribution to early stages of learning such as novelty detection iii) the cholinergic modulation of simple associative learning processes. A long-term goal of such experiments ist to provide an experimental approach that has relevance to studying mechanismes of recovery and treatment effects in patients with neurological damage, such as stroke, and neurodegenerative disease such als Alzheimers.

该项目旨在研究神经递质乙酰胆碱（ACH）在人脑学习和学习相关可塑性过程中的作用。一个更普遍的目的是在人类认知任务的背景下实施功能磁共振成像（fMRI）与药理学挑战。通过这种方法，以下问题将在一系列涉及事件相关fMRI的心理 - 药理学实验中解决：i）ACH在学习相关皮质可塑性中的作用ii）胆碱能对学习早期阶段的贡献，例如新颖性检测iii III III），简单的关联学习过程的胆碱剂调节。此类实验的长期目标是提供一种实验方法，该方法与研究神经系统损害的患者（例如中风）和神经退行性疾病（如ALS Alzheimers）的恢复和治疗作用相关。