Cholinergic modulation of learning and learning related plasticity with event-related fMRI

事件相关功能磁共振成像对学习和学习相关可塑性的胆碱能调节

• 批准号: 5212686
• 负责人: Professorin Dr. Christiane M. Thiel
• 金额: --
• 依托单位: Abteilung Biologische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 1999
• 资助国家: 德国
• 起止时间: 1998-12-31 至 2001-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5212686?language=en
• 关键词: Cholinergic; modulation; learning; related; plasticity

The project aims to investigate the role of the neurotransmitter acetylcholine (ACh) in processes of learning and learning related plasticity in the human brain. A more general aim is to implement combined functional magnetic resonance imaging (fMRI) with pharmacological challenges in the context of cognitive tasks in humans. With such an approach the following questions will be addressed in a series of psycho-pharmacological experiments involving event-related fMRI: i) the role of ACh in learning related cortical plasticity ii) the cholinergic contribution to early stages of learning such as novelty detection iii) the cholinergic modulation of simple associative learning processes. A long-term goal of such experiments ist to provide an experimental approach that has relevance to studying mechanismes of recovery and treatment effects in patients with neurological damage, such as stroke, and neurodegenerative disease such als Alzheimers.

该项目旨在研究神经递质乙酰胆碱（ACh）在人脑学习过程和学习相关可塑性中的作用。一个更普遍的目标是在人类认知任务的背景下实现功能磁共振成像（fMRI）与药理学挑战的结合。有了这样的方法，以下问题将在一系列涉及事件相关功能磁共振成像的心理药理学实验中得到解决：1)乙酰胆碱在学习相关皮质可塑性中的作用；2)胆碱能对学习早期阶段的贡献，如新颖性检测；3)胆碱能对简单联想学习过程的调节。这些实验的长期目标是提供一种与研究神经损伤（如中风）和神经退行性疾病（如阿尔茨海默病）患者的恢复机制和治疗效果相关的实验方法。