权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study of Arising Mechanism and Therapy for Endodontal Periodontal Lesion

牙髓病牙周病变发生机制及治疗研究

基本信息

批准号：
61304054
负责人：
IHACHI KATO
金额：
$ 8.77万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

We give an outline of this study. 1.Analysis of the clinical state on endodontal periodontal lesion: We collected specimens and classified them according to case histories, clinical findings and radiographical findings. Then we compared the histopathological state of the dental pulp with the clinical state. And the relationships between the proteinases such as elastase, cathepsins B, H and L in gingival crevicular fluid and clinical states were examined. 2.The study on the combination of periodontal and endodontal lesions: 1 We examined the frequency of accessory canals using the methods of Replica, SEM and image analysis. 2 We studied the diagnosing method by measuring the electric resistance value between root canal and periodontal tissue. 3 We examined the spreading pathway of inflammation from the pursuit of the derection of tissue fluid flow. As a result, endodontic lesion easily spread periodontal tissue, but only periodontal lesion with severe periodontal breakdown spread the pulp and the maxillary sinus. 3.The study on bacterial flora: Microbial density was low in root canals, but it was high in periodontal pockets. Cultivable bacterial flora was simpler than that in root canals. IgG antibody titers to some specific bacterias were high, but the kind of bacteria was different case by case. Then we examined the relationship between the treatment and the change of bacterial flor a(especially anaerobe) in root canals and periodontal pockets. As for the total number of bacteria, we could neither detect any bacteria in the canal by just one root canal treatment, nor did we find any change of the number in periodontal pockets just only by the treatments. 4.The study on the treatment: We histopathologically observed the periodontal wound healing in the case of animal tooth reimplantation. Blood coagulation factor FXIII was effetive on the wound healing.

我们给出了这项研究的大纲。1.根管牙周病的临床状况分析：收集标本，根据病史、临床表现和X线表现进行分类。然后将牙髓组织病理学状态与临床状态进行比较。并检测龈沟液中弹性蛋白酶、组织蛋白酶B、H、L等蛋白酶与临床症状的关系。2.牙周牙髓联合病变的研究：1采用X射线衍射、扫描电镜和图像分析等方法，对副根管的出现率进行了研究。2.通过测量根管与牙周组织间的电阻值，探讨了诊断方法。3从组织液流动方向的追踪来探讨炎症的传播途径。因此，根管病变容易扩散牙周组织，但只有牙周病变严重牙周破坏蔓延牙髓和上颌窦。3.细菌植物群研究：根管内微生物密度低，牙周袋内微生物密度高。根管内可培养植物群较根管内简单。对某些特定细菌的IgG抗体滴度较高，但细菌的种类不同。观察根管及牙周袋内细菌（尤其是厌氧菌）的变化与治疗的关系。至于细菌总数，我们既不能通过一次根管治疗在根管中检测到任何细菌，也没有发现牙周袋中的细菌数量仅通过治疗有任何变化。4.治疗研究：对动物牙齿再植后的牙周伤口愈合进行组织病理学观察。凝血因子FXIII对创面愈合有促进作用。