Midbrain Control of Cold Shivering

中脑控制冷颤

基本信息

  • 批准号:
    61570087
  • 负责人:
  • 金额:
    $ 1.22万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1986
  • 资助国家:
    日本
  • 起止时间:
    1986 至 1987
  • 项目状态:
    已结题

项目摘要

This project was aimed to clarify whether cold shivering is controlled by midbrain temperature or not. Single gamma efferents were isolated in the preparations of rat whose bilateral preoptic and anterior hypothalamus were electrolytically lesioned to eliminate the influences from the higher center for shivering, and changes in the discharge activity were examined while the midbrain was cooled or warmed by means of a water perfused thermode. Under the normal midbrain temperature, 36% of 64 gamma fibers isolated exhibited periodic fluctuations in spontaneous discharge whereas the rest sustained spontaneous discharge. Of 38 gamma fibers, including both type of fibers, examined for thier thermal reactiveness, 71% produced an increase or a decrease in discharge frequency to a fall below or a rise above the normal midbrain temperature, respectively. Temperature dependency of discharge frequency obtained in the range below 37.5゜C(-1.5<plus-minus>0.1 imp./sec/゜C in perfusion temperature) was … More smaller than the one in the range above 37.5゜C(2.8<plus-minus>0.5 imp./sec/゜C). This behaviour of gamma activity parallels the general pattern of thermoregulatory responses involved inmaintaining a heat balance, e.g., heat production is facilitation in the hypothermic range and suppressed in hyperthermic range. The afferent responses from the muscle spindle primary(43) and secondary endings(7) in the gastrocunemius et soleus to stretches of the muscle which were repeatedly applied during midbrain cooling or warming were analyzed by measuring peak frequency, static frequency and the dynamic index in each stretch response. It was found that midbrain cooling produced not only dynamic gamma activation but also static gamma activation, with the prevalence of former(63%) over the latter(29%). These results indicate that the descending signals derived from the thermosensitive structures in the midbrain also influence gamma motor activities, suggesting that shivering threshold could be altered therpmen Less
本项目旨在阐明冷寒战是否由中脑温度控制。在电损毁双侧视前区和下丘脑前部以消除震颤的高级中枢影响的大鼠标本中分离出单个γ传出神经,并通过水灌注热电极观察中脑冷却或加温时放电活动的变化。在正常中脑温度下,36%的64个γ纤维分离出的自发放电表现出周期性波动,而其余的持续自发放电。38个伽马纤维,包括这两种类型的纤维,检查其热反应性,71%产生的放电频率的增加或减少,以低于或高于正常的中脑温度,分别下降或上升。在低于37.5 ° C(-1.5 <plus-minus>0.1 imp./ sec/℃灌注温度) ...更多信息 小于37.5 ℃以上范围内的温度(2.8 <plus-minus>± 0.5 imp./ sec/sec C)。γ活动的这种行为与维持热平衡所涉及的体温调节反应的一般模式相似,例如,产热在低体温范围内是促进的,而在高体温范围内是抑制的。在中脑降温或升温过程中,通过测量每次牵拉反应的峰值频率、静态频率和动态指数,分析了腹楔肌和比目鱼肌肌梭初级终末(43个)和次级终末(7个)对肌肉牵拉的传入反应。结果发现,中脑冷却不仅产生动态伽马激活,而且产生静态伽马激活,前者(63%)的患病率高于后者(29%)。这些结果表明,来自中脑温度敏感结构的下行信号也会影响γ运动活动,这表明颤抖阈值可以通过治疗改变。

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Haruhiko Sato: "Effect of stimulation of nucleus raphe magnus of gamma discharge activity in rats." J. of the Physiological Society of Japan. 49. 569 (1987)
Haruhiko Sato:“刺激大鼠中缝大核对伽马放电活动的影响。”
  • DOI:
  • 发表时间:
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  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Haruhiko Sato and Eckhart Simon: Sattelite Symposium of the XXXth Congress of International Union of Physiological Science,July,1986.
Haruhiko Sato 和 Eckhart Simon:国际生理科学联合会第 30 届大会卫星研讨会,1986 年 7 月。
  • DOI:
  • 发表时间:
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    0
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  • 通讯作者:
Haruhiko Sato and Takeshi Hashitani: "Facilitation and suppression of gamma motor nerve activity induced by changes in temperature of the midbrain reticular formation of rats." Experimental Neurology.
Haruhiko Sato 和 Takeshi Hashitani:“大鼠中脑网状结构温度变化诱导的伽玛运动神经活动的促进和抑制。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Haruhiko SATO: Journal of the Physiological Society of Japan. 48. 402 (1986)
佐藤晴彦:日本生理学会杂志。
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  • 影响因子:
    0
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SATO Haruhiko其他文献

SATO Haruhiko的其他文献

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{{ truncateString('SATO Haruhiko', 18)}}的其他基金

Analysis regarding governmental support for the mental and physical load carried by a husband and wife, and its effect on the national birthrate.
政府对夫妻精神和身体负担的支持及其对国民出生率的影响分析。
  • 批准号:
    24530312
  • 财政年份:
    2012
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Automation of inductive theorem proving in equational logic with multi-context reasoning
多上下文推理方程逻辑中归纳定理证明的自动化
  • 批准号:
    22700021
  • 财政年份:
    2010
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
The research refines factors including the number of births, classification of families, and regional comparisons.
该研究细化了出生人数、家庭分类和地区比较等因素。
  • 批准号:
    21530271
  • 财政年份:
    2009
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
24-hour postural management program for children with severe cerebral palsy and its possibilities to prevent deformities
重度脑瘫儿童24小时姿势管理方案及其预防畸形的可能性
  • 批准号:
    21500489
  • 财政年份:
    2009
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Preventing musculoskeletal deformities in children with severe cerebral palsy based on experiences from a wide variety of postures and movements
根据各种姿势和动作的经验,预防严重脑瘫儿童的肌肉骨骼畸形
  • 批准号:
    18500420
  • 财政年份:
    2006
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Influence of running exercise on γmotoneuron activity
跑步运动对γ运动神经元活性的影响
  • 批准号:
    09670079
  • 财政年份:
    1997
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study on the modulation of temperature signals from the skin by the nucleus raphe magnus and subcoeruleus
中缝大核和蓝下肌对皮肤温度信号调节的研究
  • 批准号:
    03670082
  • 财政年份:
    1991
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Differences of Fatigability in Human Skeletal Muscles
人体骨骼肌疲劳性的差异
  • 批准号:
    60540534
  • 财政年份:
    1985
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
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