Study on the modulation of temperature signals from the skin by the nucleus raphe magnus and subcoeruleus
Study on the modulation of temperature signals from the skin by the nucleus raphe magnus and subcoeruleus
批准号:
03670082
负责人:
SATO Haruhiko
金额:
$1.28万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1991
资助国家:
日本
项目状态:
已结题
起止时间:
1991 至 1992
中文摘要
1.在乌拉坦麻醉大鼠的阴囊皮肤温度的无害范围内(10-40゚℃),对背角细胞进行细胞外记录。温度反应的背角细胞(65个)分为两组:温敏反应细胞(48个)和冷反应细胞(17个),温敏反应细胞(48个)通过皮肤温暖反应增加放电频率,冷反应细胞(17个)通过皮肤咕咕叫冷反应增加放电频率。方法:1.研究电刺激中缝大核(NRM)和蓝斑下核(SC)对其放电活动的影响。电刺激NRM和SC的效应被发现表现为部分或完全抑制热或冷反应。背景活动基本不受影响。大部分(95%)温敏细胞在刺激NRM时温度反应减弱,而大多数(79%)冷反应细胞在SC刺激下温度反应减弱。在4个温应性细胞中,5-羟色胺拮抗剂甲基丝氨酸(1 mg/kg)静脉注射可部分拮抗NRM引起的体温反应抑制。这种NRM诱发的抑郁被认为是由5-羟色胺能中缝脊髓通路介导的。这些结果表明,中缝和蓝髓下脊髓通路下行调制了有助于中枢体温调节的冷暖信号在脊髓中的传递。
英文摘要
1. Extracellular recordings were made from dorsal horn cells responsive to temperature changes in the innocuous range (10-40゚C) of scrotal skin temperature in the lumbosacral segment of urethane-anesthetized rats. The temperature responsive dorsal horn cells (65) were classified into two groups : warm-responsive cells (48) showing an increase in firing rate by skin warming, warm-response, and cold-responsive cells (17) showing an increase in firing rate by skin cooing, cold-response. The effects of electrical stimulation in the nucleus raphe magnus (NRM) and subcoeruleus (SC) on their firing activity were studied.2. Effect of electrical stimulation in the NRM as well as in the SC was found to be characterized by a partial or complete depression of warm- or cold-responses. The background activity mostly remained unaffected.3. Depression of temperature response occurred in most (95%) of warm-responsive cells by NRM stimulation, whereas in the majority (79%) of cold-responsive cells by SC stimulation.4. In four warm-responsive cells, NRM-evoked depression of their temperature responses was partially antagonized by Serotonin antagonist, Methysergide (1 mg/kg, i.v.). Such NRM-evoked depression was suggested to be mediated by serotonergic raphe-spinal pathways.5. The results suggest that the raphe- and subcoeruleo-spinal pathways descendingly modulate the spinal transmission of warm and cold signals contributing to central thermoregulation.
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Haruhiko SATO and Hitoo NISHINO: "Raphe-spinal and subcoeruleo-spinal modulat-ion of temperature signal tranasmission in rats." Abstracts of 20th Annual Meeting of Ameri-can Society for Neuroscience at St.Louis. P.96 (1990)
Haruhiko SATO 和 Hitoo NISHINO:“大鼠温度信号传递的中缝脊髓和蓝核下脊髓调节。”
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通讯作者:
Haruhiko Sato et al.: "Temperature signal modulation by raphe- and subcoeruleo-spinal pathways of rats." Jap. J. Physiol.41. S330 (1991)
Haruhiko Sato 等人:“大鼠中缝和蓝核下脊髓通路的温度信号调节。”
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Haruhiko Sato: "Modulation of thermoafferent signals and thermoregulatory response by brain stem." in Symposium on Thermoregulation and related systems in 70th Congress of the Physiological Society of Japan,Yamanashi. April. (1993)
Haruhiko Sato:“脑干对热传入信号和温度调节反应的调节。”
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Haruhiko Sato et al.: "Descending modulation of temperature signals by the nucleus raphe magnus and subcoeruleus in rats." Jap. J. Physiol.40. S281 (1990)
Haruhiko Sato 等人:“大鼠中缝大核和蓝下核对温度信号的降序调节。”
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共 23 条
Analysis regarding governmental support for the mental and physical load carried by a husband and wife, and its effect on the national birthrate.
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Midbrain Control of Cold Shivering
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Differences of Fatigability in Human Skeletal Muscles
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海外基金