Study on sympathetic purinergic transmission in blood vessels

血管内交感嘌呤能传递的研究

• 批准号: 61570097
• 负责人: MURAMATSU Ikunobu
• 金额: $ 1.47万
• 依托单位: Fukui Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570097/
• 关键词: Blood vessels; Sympathetic transmission; Sympathetic purinergic response; アドレナリン伝達機序; プリン作動性反応; 交感神経性反応; 【P_2】-プリン受容体

Electrical transmural stimulatin of isolated mesenteric artery of the dog produced a transient contractin which consisted of adrenergic and non-adrenergic components. In contrast to the adrenergic component, the nonadrenergic component was resistant to prazosin and other adrenoceptor-blocking agents. However, the nonadrenergic component was completely blocked by guanethidine and by desensitization of P_2-purinoceptors with ,<beta>-methylene ATP. Desensitization of P_2-purinoceptors also inhibited the contractile response to ATP but not the adrenergic responses induced by electrical transmural stimulation and exogenous noradrenaline. These results suggest that the nonadrencergic contraction induced by electrical transmural stimulation is a sympathetic, purinergic response. Such purinergic responses were observed in the dog basilar and middle cerebral arteries andin the mesenteric, portal and saphenous veins, suggesting that the sympathetic purinergic transmission may paly a physiologically important role in the circulatory system.

经壁电刺激犬离体肠系膜动脉可产生由肾上腺素能和非肾上腺素能成分组成的短暂性收缩素。与肾上腺素能成分相反，非肾上腺素能成分对哌唑嗪和其他肾上腺素受体阻滞剂有抗性。然而，非肾上腺素能成分被胍乙啶和p_2 -嘌呤受体与< β >-亚甲基ATP的脱敏完全阻断。p_2 -嘌呤受体的脱敏也抑制ATP的收缩反应，但不抑制电跨壁刺激和外源性去甲肾上腺素引起的肾上腺素能反应。这些结果表明，电跨壁刺激引起的非肾上腺素性收缩是一种交感嘌呤能反应。在狗的大脑基底动脉和大脑中动脉以及肠系膜、门静脉和隐静脉中观察到这种嘌呤能反应，表明交感嘌呤能传递可能在循环系统中发挥重要的生理作用。

项目成果

Ikunobu Muramatsu: British J.Pharmacology. 87. 478-480 (1986)

Ikunobu Muramatsu：英国药理学杂志。

I.Muramatsu: Br.J.Pharmacol.87. 478-480 (1986)

I.Muramatsu：Br.J.Pharmacol.87。

Ikunobu Muramatsu: "Evidence for sympathetic, purinergic transmission in the mesenteric artery of the dog" British J. Pharmacology. 87. 478-480 (1986)

Ikunobu Muramatsu：“狗肠系膜动脉中交感神经、嘌呤能传递的证据”英国药理学杂志。

I.Muramatsu: Br.J.Pharmacol.(1987)

I.Muramatsu：Br.J.Pharmacol.(1987)