Gastric Mucosal Damage and Prostaglandin E_2 in Rats with Renal Failure

目的：探讨胃粘膜前列腺素E_2 （PGE_2）的作用及其影响；Solcoserly;迷走神经切断术对肾功能衰竭大鼠胃粘膜损害的影响，采用4/6 ~ 5/6肾切除术制备肾功能衰竭大鼠。PGE_2值随肾功能衰竭的严重程度而降低。诱导应激后，迷走神经切开术对溃疡的抑制效果最好，其次为索克赛利，PGE_2给药7 d后胃黏膜PGE_2值降低，这可能是负反馈机制的结果。已知会增加胃粘膜PG值的Solcoserly在肾衰竭中没有这种作用。然而，胃粘液增加最多。迷走神经切开术后PGE_2值未见明显下降。此外，由于迷走神经切开术诱导胃酸减少（这是一个侵略性因素），它对抑制应激后溃疡最有效。结果表明：1.肾衰大鼠；胃粘膜PGE_2值被认为是胃粘膜损伤的重要因素。2. 迷走神经切开术被认为是最有效的预处理。

In order to study the role of gastric mucosal prostaglandin E_2 (PGE_2) and the effect of PGE_2; of Solcoserly; and of vagotomy on gastric mucosal damage in renal failure, rats with renal failure were prepared by stepwise 4/6 -5/6 nephrectomy.PGE_2 values tended to decrease in relation to the severity of renal failure. After inducing stress, vagotomy was most effective in suppressing ulcers, followed by Solcoseryl and PGE_2 values in the gastric mucosa decreased when PGE_2 was administered for 7 days, and this finding may have been the result of a negative feedback mechanism. Solcoserly, which is known to increase gatric mucosal PG values, did not have this effect in renal failure. However, the gastric mucus increased most with Solcoseryl. No decreaseein PGE_2 values after vagotomy was observed. Furthermore, as vagotomy induced a decrease in gastric acidity (which is an aggressive factor), it was most effective in suppressing ulceration after stress.It was concluded as follows in rats with renal failure: 1. PGE_2 values in the gastric mucosa were considered an imporetant factor in gastric mucosal damage. 2. Vagotomy was considered the most effective pretreatment.