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Trarable ischemic neuronal damage

可治疗的缺血性神经元损伤

基本信息

批准号：
61570706
负责人：
KIRINO Takaaki
金额：
$ 1.28万
依托单位：
Teikyo University Shool of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

Brier transient forbrain ischemia in to Mongolian gearbil produces a selective neuronal damage in the hippocampus. Immeciately follwing ishemia, prentobarbvtal,diazapem, or nizotenone were given in gerbils. The neuronal density in the CA1 sector showed a significant inforease in the treated goups. when froug administration was delayed fro longer than 15 minutes, however, no definite eccets were found. The mechanism of selective vulnerability of ischemia is not fully understood. An experiment of cerbellar ischemia was done in order to compare thr pathological change with that og thr hippocampus. %cerebella purkinje cells showed ishiemic cell damage following 10 min of comression ischemia. The alteration was, however, much faster than taht in the hippocampus. The underlying mechanism seems to be different. Focal cetebral ischiemia is more frequently sdeen in clinical case. To tsudy the reversibility of neurons in focal ischema, rats were subjected to permanent unilatearal middle cerebral artery occtusion. In ischemic region, rapid prograssion in infaction was noticed and slow process as is seen in the hippocampus was not recognized. On the other hand, in the distant areas of the brain, such as the thalamus, and substntia nigra, a slow buyt proufnd morphological changes were obsearved. Transizent focal cerebral ischemia in the rat is now being studeid in order to examine the possibility of reversible neuronal change following brief focal ischemia.

短暂性脑缺血对蒙古大鼠海马区产生选择性神经元损伤。沙土鼠一般给予缺血、巴比妥钠、安定、尼唑酮等治疗。治疗组大鼠CA1区神经元密度明显减少。然而，当弗劳格给药延迟超过15分钟时，没有发现明确的瘀斑。目前对脑缺血选择性易损性的机制尚不完全清楚。进行了小脑缺血实验，并与海马区的病理改变进行了比较。压迫性缺血10min，小脑浦肯野细胞出现缺血性细胞损伤。然而，这种变化要比海马体的变化快得多。潜在的机制似乎有所不同。局灶性脑缺血多见于临床病例。为研究局灶性脑缺血神经元的可逆性，采用永久性单侧大脑中动脉闭塞模型。在缺血区，可观察到脑梗塞的快速突起，而不能识别海马区的缓慢过程。另一方面，在大脑的远端区域，如丘脑和黑质，观察到了缓慢的购买和形态变化。为了研究短暂性局灶性脑缺血后神经元可逆性改变的可能性，目前正在对大鼠短暂性局灶性脑缺血进行研究。