Role of Neuropilin-1 on Lung Macrophages during Pulmonary Inflammation

Neuropilin-1 在肺部炎症过程中对肺巨噬细胞的作用

• 批准号: 521669965
• 负责人: Professor Dr. Johannes Andreas Eble
• 金额: --
• 依托单位: Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/521669965?language=en
• 关键词: Role; Neuropilin; Lung; Macrophages; during

This project will investigate the role of Nrp1-ligands on monocyte recruitment and macrophage polarization in the lung. In this project proposal, the principal investigators aim to provide novel insight into the molecular interactions and signaling partners of Nrp1 on macrophages and to characterize the role of myelo-monocytic Nrp1 in the pathobiology of acute pulmonary inflammation and resolution. Ultimately, the results will initiate the translation of the findings into the development of an Nrp1 inhibitor which preferentially targets lung macrophages for therapeutic benefit.

本项目将研究Nrp1配体在肺单核细胞募集和巨噬细胞极化中的作用。在这个项目提案中，主要研究人员的目标是提供新的见解Nrp1对巨噬细胞的分子相互作用和信号伴侣，并表征骨髓单核细胞Nrp1在急性肺部炎症和解决的病理生物学中的作用。最终，这些结果将开始将这些发现转化为Nrp1抑制剂的开发，该抑制剂优先靶向肺巨噬细胞以获得治疗益处。