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CHOLINE METABOLISM AND AMOUNTS OF C_1-COMPOUNDS IN RAT LIVER

大鼠肝脏中的胆碱代谢和 C_1-化合物的量

基本信息

批准号：
62560076
负责人：
TSUGE Haruhito
金额：
$ 1.34万
依托单位：
GIFU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

In the choline deficient rats, the activities of hepatic choline dehydrogenase (EC 1.1.99.1) and diamine oxidase (EC 1.4.3.6)from small intestine, both are assumed to contain a new type coenzyme, covalently-bound pyrroloquinoline quinone (PQQ), were investigated when rats were fed diets consisting mainly of amino acid mixtures with of without PQQ.Choline deficiency from diet induced severe fatty liver when conventional rats were fed a diet consisting of amino acid mixtures in spite of the presence or absence of PQQ. However, the activities of choline dehydrogenase in liver together with diamine oxidase in small intestine did not alter significantly, whether the diet was fed with or without PQQ. Similar results were obtained when the germ-free rats were fed diets consisting mainly of amino acid mixtures with enough choline.

在胆碱缺乏大鼠中，当给大鼠喂食主要由氨基酸混合物组成的饮食时，研究了来自小肠的肝胆碱脱氢酶（EC 1.1.99.1）和二胺氧化酶（EC 1.4.3.6）的活性，这两种酶被认为都含有新型辅酶，共价结合的吡咯并喹啉醌（PQQ）。 PQQ。当传统大鼠喂食由氨基酸混合物组成的饮食时，无论是否存在 PQQ，饮食中的胆碱缺乏都会诱发严重的脂肪肝。然而，无论饮食中是否添加 PQQ，肝脏中的胆碱脱氢酶以及小肠中的二胺氧化酶的活性都没有显着变化。当给无菌大鼠喂食主要由氨基酸混合物和足够胆碱组成的饮食时，也得到了类似的结果。