Parental Occupational and Home Exposure and Risk for Childhood Cancers

目的：评估儿童时期前体细胞肿瘤的可能病因的概念前、出生前和出生后环境因素的假说。方法：设计两项独立但同时进行的社区病例对照研究，以检验儿童癌症的危险因素和估计回忆偏倚。数据是通过对母亲的访谈和对病例和对照父亲的邮寄问卷获得的。其中急性淋巴细胞白血病123例，急性髓系白血病23例，神经母细胞瘤53例。结果：在与人群对照的白血病病例的多因素分析中，母亲的X线照射、孕期苯并素的使用和饮酒、父亲在确诊前接触油漆的OR值显著高于对照组，而泡菜摄入量、苯并素的使用、孕期接触杀虫剂、孕前1年接触动物和父亲孕前1年的化学物质暴露、孕期接触农药等因素与医院对照组相比，差异有统计学意义。结论：父母暴露于环境因素可能是儿童白血病的病因。

Purpose : The objectives were to assess the hypotheses of preconceptual, prenatal and postnatal environmental factors which were considered as possible etiologic agents for the neoplasms of the precursor cell in childhood.Methods : Two independently but simultaneously conducted community based case-control studies are designed to examine the risk factors of childhood cancers and to estimate recall bias. Data were obtained by interview with mothers and postal questionnaire with fathers of cases and controls. 123 ALL, 23 AML and 53 Neuroblastoma were identified. Hospital control group were matched sex and age and population control group were matched place of residence, age and sex.Results : Mothers' X-ray exposure, Benzin use and alcohol intake during pregnancy, fathers' paint exposure before diagnosis had significantly high odds ratios in multivariate analyses of data set of leukemia cases with population control, while pickles intake, Benzin use, exposure to spray pesticide during pregnancy and contact with animals before diagnosis and fathers' chemical exposure at 1 year before pregnancy and pesticide exposure during pregnancy had high odds ratios in data sets of leukemia with hospital control.Conclusion : The results suggested parental exposure to environmental factors may play an etiologic role in childhood leukemia.