Parental Occupational and Home Exposure and Risk for Childhood Cancers

目的：目的是评估假设的preconceptual，产前和产后的环境因素，被认为是可能的病原体的肿瘤的前体细胞在childhood.Methods：两个独立的，但同时进行的社区为基础的病例对照研究的目的是检查儿童癌症的危险因素和估计回忆偏差。通过对病例组和对照组母亲的访谈和对父亲的邮寄问卷获得数据。ALL 123例，AML 23例，神经母细胞瘤53例。医院对照组为性别、年龄相匹配的对照组，人群对照组为居住地、年龄、性别相匹配的对照组。在人群对照的白血病病例数据集的多因素分析中，母亲在怀孕期间的X射线暴露、苯甲酸使用和酒精摄入、父亲在诊断前的油漆暴露具有显著的高比值比，而泡菜摄入、苯甲酸使用、在医院控制的白血病数据集中，妊娠期喷洒农药暴露、诊断前接触动物、父亲妊娠前1年化学品暴露和妊娠期农药暴露具有高比值比。结果提示，父母接触环境因素可能在儿童白血病的发病中起一定作用。

Purpose : The objectives were to assess the hypotheses of preconceptual, prenatal and postnatal environmental factors which were considered as possible etiologic agents for the neoplasms of the precursor cell in childhood.Methods : Two independently but simultaneously conducted community based case-control studies are designed to examine the risk factors of childhood cancers and to estimate recall bias. Data were obtained by interview with mothers and postal questionnaire with fathers of cases and controls. 123 ALL, 23 AML and 53 Neuroblastoma were identified. Hospital control group were matched sex and age and population control group were matched place of residence, age and sex.Results : Mothers' X-ray exposure, Benzin use and alcohol intake during pregnancy, fathers' paint exposure before diagnosis had significantly high odds ratios in multivariate analyses of data set of leukemia cases with population control, while pickles intake, Benzin use, exposure to spray pesticide during pregnancy and contact with animals before diagnosis and fathers' chemical exposure at 1 year before pregnancy and pesticide exposure during pregnancy had high odds ratios in data sets of leukemia with hospital control.Conclusion : The results suggested parental exposure to environmental factors may play an etiologic role in childhood leukemia.