Parental Occupational and Home Exposure and Risk for Childhood Cancers

目的：目的是评估孕前、产前和产后环境因素的假设，这些因素被认为是儿童前体细胞肿瘤的可能病因。方法：两项独立但同时进行的基于社区的病例对照研究旨在检查儿童癌症的危险因素并估计回忆偏倚。数据通过对母亲的访谈和对病例和对照组父亲的邮寄问卷获得。123例ALL， 23例AML， 53例神经母细胞瘤。医院对照组匹配性别和年龄，人口对照组匹配居住地、年龄和性别。结果:在人口控制的白血病病例数据集的多变量分析中，母亲的x射线暴露、孕期使用Benzin和酒精摄入量、父亲在诊断前的油漆暴露具有显著高的比值比，而泡菜摄入量、Benzin使用、在医院对照的白血病数据集中，妊娠期接触喷雾农药和诊断前与动物接触、妊娠前1年父亲接触化学物质和妊娠期接触农药具有较高的比值比。结论：父母环境暴露可能在儿童白血病发病中起一定的致病作用。

Purpose : The objectives were to assess the hypotheses of preconceptual, prenatal and postnatal environmental factors which were considered as possible etiologic agents for the neoplasms of the precursor cell in childhood.Methods : Two independently but simultaneously conducted community based case-control studies are designed to examine the risk factors of childhood cancers and to estimate recall bias. Data were obtained by interview with mothers and postal questionnaire with fathers of cases and controls. 123 ALL, 23 AML and 53 Neuroblastoma were identified. Hospital control group were matched sex and age and population control group were matched place of residence, age and sex.Results : Mothers' X-ray exposure, Benzin use and alcohol intake during pregnancy, fathers' paint exposure before diagnosis had significantly high odds ratios in multivariate analyses of data set of leukemia cases with population control, while pickles intake, Benzin use, exposure to spray pesticide during pregnancy and contact with animals before diagnosis and fathers' chemical exposure at 1 year before pregnancy and pesticide exposure during pregnancy had high odds ratios in data sets of leukemia with hospital control.Conclusion : The results suggested parental exposure to environmental factors may play an etiologic role in childhood leukemia.