Regulatory mechanism of atrial natriuretic peptide secretion and degradation ; especially in pathophysiological status

心房钠尿肽分泌和降解的调控机制；

• 批准号: 62570403
• 负责人: MARUMO Fumiaki
• 金额: $ 1.15万
• 依托单位: Tokyo Medical and Dental University (1988)Kitasato University (1987)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570403/
• 关键词: atrial natriuretic peptide; alpha-ANP; beta-ANP; congestive heart failure; degradation; renal failure; cerebrospinal fluid; イヌ; 心房性Na利尿ホルモン; 存在様式; 尿中; 髄液中心房性Na利尿ホルモンAtrial Naturiuretic Peptide; dog; Molecular from of ANP

Purposes of our study are, 1) to clarify regulatory mechanism of atrial natriuretic peptide (ANP) secretion and degradation in physiological status of animals and human, 2) to clarify effects of diseases such as congestive heart disease, renal diseases or hemodialysis on ANP secretion, 3) to clarify whether molecular forms of ANP in the plasma and urine have specificity in some diseases, 4) to clarify whether ANPs secreted from the atrium and the brain are independent or not.In results, all questions we proposed have completely or patially resolved in attached title of papers. Finally, we will advance our study progressively and investigate correlation between ANP and other peptides such as endothelin or brain natriuretic peptide.

我们的研究目的是：1)阐明动物和人在生理状态下心房钠肽（ANP）分泌和降解的调控机制；2)阐明充血性心脏病、肾脏疾病或血液透析等疾病对ANP分泌的影响；3)阐明血浆和尿液中ANP的分子形态在某些疾病中是否具有特异性；4)阐明心房和大脑分泌的ANP是否具有独立性。结果，我们提出的所有问题都在附件的论文标题中得到了完全或部分的解决。最后，我们将进一步深入研究ANP与其他肽如内皮素或脑利钠肽的相关性。

项目成果

K. Ando; N. Umetani; T. Kurosawa; S. Takeda; Y. Katoh; F. Marumo: "Atrial Natriuretic Peptide in Human Urine" Klinische Wochen-schrift. 66. 768-772 (1988)

K.安藤；

Fumiaki MARUMO; Hisato SAKAMOTO; Naoki UMETANI; Michihito OKUBO: "Atrial Natriuretic Peptide in Kidney of Renal Disease Patients and Healthy Persons" Endocrinol. Japon.35. 523-529 (1988)

丸茂文明；

Sakamoto, H. and Marumo, F.: Acta endocrinologica.

Sakamoto, H. 和 Marumo, F.：内分泌学学报。

Marumo,F.; Kurosawa,T.; Takeda,S.; Katoh,Y.; Hasegawa,N.; Marumo,F.: Klinische Wochen-schrift. 66. 675-681 (1988)

丸茂，F.；

Ando,K.; Umetani,N.; Kurosawa,T.; Takeda,S.; Katoh,Y.; Marumo,F.: Klinische Wochen-schrift. 66. 768-772 (1988)

安藤，K。