Regulatory mechanism of atrial natriuretic peptide secretion and degradation ; especially in pathophysiological status

我们的研究目的是：1)阐明动物和人在生理状态下心房钠肽（ANP）分泌和降解的调控机制；2)阐明充血性心脏病、肾脏疾病或血液透析等疾病对ANP分泌的影响；3)阐明血浆和尿液中ANP的分子形态在某些疾病中是否具有特异性；4)阐明心房和大脑分泌的ANP是否具有独立性。结果，我们提出的所有问题都在附件的论文标题中得到了完全或部分的解决。最后，我们将进一步深入研究ANP与其他肽如内皮素或脑利钠肽的相关性。

Purposes of our study are, 1) to clarify regulatory mechanism of atrial natriuretic peptide (ANP) secretion and degradation in physiological status of animals and human, 2) to clarify effects of diseases such as congestive heart disease, renal diseases or hemodialysis on ANP secretion, 3) to clarify whether molecular forms of ANP in the plasma and urine have specificity in some diseases, 4) to clarify whether ANPs secreted from the atrium and the brain are independent or not.In results, all questions we proposed have completely or patially resolved in attached title of papers. Finally, we will advance our study progressively and investigate correlation between ANP and other peptides such as endothelin or brain natriuretic peptide.