Study on human parvovirus B19 infections

对日本人细小病毒B19的临床表现进行了调查，因为除传染性红斑外未作任何检查。资料明确显示，该病毒可引起溶血性贫血患者的发热性疾病、不明原因的疹性疾病、血管性紫癜、点疹、多发性关节炎、再生危象、免疫抑制状态下的急性或持续性贫血以及胎儿疾病。2 . 1968年在感染性红斑患儿血清中检出人细小病毒B19 DNA，可能是史上最早发现的病毒，绝对证实了感染性红斑的病因。自1981年3月在大阪以来，全日本共发现31例与该病毒有关的再生危机。基础疾病为遗传性球形细胞增多症30和葡萄糖-6-磷酸脱氢酶缺乏症1，在国际上尚属首次观察。福冈、北九州、别府和大阪6例因B19感染而死亡的非免疫性积水胎儿。福冈市1.5万名活产婴儿中至少有3人在怀孕期间死于该病毒。一例因病毒感染而流产。人血浆衍生药物，一批凝血因子9复合物，

Clinical manifestations associated with human parvovirus B19 in Japan were investigated, because no examination had been done except erythema infectiosum.1. The data clearly showed that the virus caused febrile illness, unspecified exanthematous disease, vascular purpura, petechial rash, polyarthritis, aplastic crisis in patient with hemolytic anemias, acute or persistent anemia in patient under immunosuppressive state and fetal disorders.2. Human parvovirus B19 DNA was detected in sera of children with erythema infectiosum in 1968, which might be the oldest found in history of the virus, and absolute confirmation of the cause of erythema infectiosum.3. Thirty one cases of aplastic crisis were revealed in association with the virus in allover Japan, back to March 1981, Osaka. Underlying diseases were hereditary spherocytosis 30 and glucose-6-phosphate dehydrogenase deficiency 1, which was the first observation in the world.4. Six death cases of nonimmunologic hydrops fetalis were due to the B19 infection in Fukuoka, Kitakyushu, Beppu and Osaka. At least 3 of 15,000 live birth were killed with the virus during pregnancy in Fukuoka city. One abortion was confirmed due to the virus infection.5. Human plasma derived drug, one lot of the coagulation factor 9 complex,