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A Study of the clinical application of the positron labeled compounds

正电子标记化合物的临床应用研究

基本信息

批准号：
62570467
负责人：
FURUDATE Masayori
金额：
$ 1.66万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1989
项目状态：
已结题

项目摘要

Recently, ^<18>F-deoxyglucose(FDG) has been used as a tumor seeking agent. The theory of ^<18>F-FDG accumulation in tumor is more understandable than that of ^<67>Ga citrate, but the sensitivity of tumor diagnosis is not excellent. To enhance the tumor visualization, dynamic images were analyzed by the factor analysis in cancer patients. After IV administration of ^<18>F-FDG, dynamic images were obtained sequentially by gamma camera equipped with a special high energy collimator for positron and recorded in a computer system. Whole body images were taken at 60 minutes after administration. The factor analysis of the dynamic images shows the margin of the tumor clearly and contributes the sensitivity of tumor diagnosis.Next we studied the accumulation rate of FDG to the thyroid gland using some rats. After IV administration of ^<18>F-FDG, the rats were killed by decapitation sequentially and the thyroid gland were removed, weighed, and countered by the well-type scintillation counter. In normal rats, accumulation ratio of ^<18>F-FDG were slightly high at 60 minutes and similar to both low iodine diet rats and TRH administrated rats. Lastly we studied the detection of experimental animal thyroid cancer by FDG.The rats were transplanted the cultured human thyroid cancer. We studied the accumulation of FDG to the cultured cancer partly using ^<18>F-FDG by the autoradiography, and partly using ^<18>F-FDG by PET study. As the result of this study, we found the tumor accumulation of both ^<14>F-FDG and ^<18>F-FDG to the transplanted thyroid cancer. These results suggest that accumulation of ^<18>F-FDG may be of clinical diagnostic value for cancer detection.

最近，13 <18>F-脱氧葡萄糖（FDG）已被用作肿瘤寻找剂。肿瘤<18>中~ 1F-FDG蓄积的理论较~ 1Ga枸橼酸盐更容易理解<67>，但对肿瘤诊断的敏感性不高。为了增强肿瘤的可视化，对肿瘤患者的动态图像进行因子分析。静脉注射~（13）F-FDG后<18>，用装有正电子专用高能准直器的γ照相机连续获得动态图像，并记录在计算机系统中。在给药后60分钟拍摄全身图像。动态图像的因子分析能清晰地显示肿瘤的边缘，有助于肿瘤诊断的敏感性。其次，我们用部分大鼠研究了FDG在甲状腺的蓄积率。静脉注射14 F-FDG后<18>，将大鼠断头处死，取出甲状腺，称重，用井型闪烁计数器计数。在正常大鼠中，60分钟时~ 1F-FDG蓄积率<18>稍高，与低碘饮食大鼠和TRH给药大鼠相似。最后，对FDG检测实验动物甲状腺癌进行了研究。用<18>放射自显影法和正电子发射计算机断层扫描法分别研究了~（135）F-FDG和~（135）<18>F-FDG在培养的肿瘤细胞中的蓄积情况。本研究结果发现，<14><18>在甲状腺移植瘤中，~ 1F-FDG和~ 1F-FDG均存在肿瘤蓄积。这些结果表明，14 F-FDG的积累<18>可能对癌症检测具有临床诊断价值。