Studies on the Synthesis of Physiological Active Terpenes and Development of New Synthetic Methods

1.生理活性萜的合成。(1)烯丙基硅烷化醛分子内环化合成eudsman - α -亚甲基-6,12-olide和-8,12-olide。(2)甲酰化烯酰卤化物分子内环合成α -亚甲基- γ -内酯的方法(3)生理活性戊二酚的合成：乙酸金樟醇、马兜铃醇-9-烯-3-醇和德尼醇-三冬苷和11-脱水- -三冬苷微生物转化的研究。(1)黑弧菌对三冬氨酸的微生物羟基化作用。(2)尼黑曲霉对11-脱氢桑托宁的微生物羟基化作用。环氧亚砜在有机合成中的应用(1)通过α， β -环氧亚砜合成α -取代羰基化合物、α， β -不饱和酮和碳同源羰基化合物酯的新方法。(2)镁盐诱导α， β -环氧亚砜开孔。-氯酮、-烷氧酮的合成。(3)基于羟基的开环环氧亚砜合成α -酰基、3-酮和螺环醚的新方法。(4) 1-氯烷基苯基亚砜和4-（苯基硫代）丁醛通过α， β -环氧亚砜立体选择性合成（E - 1-酰基丁二烯）。(5)基于分子内自由基环化的环氧亚砜环化新方法。(6)以α， β -环氧亚砜为原料合成醛醇及其烯醇酸酯的新方法。以光学活性对甲苯亚砜基为手性助剂的新型不对称合成。(1)手性环氧化合物和烯丙醇的新合成方法。(2) 1-氯-对甲基亚砜的实用合成方法及(+)-异戊二烯和(-)-反异戊二烯的不对称合成新方法。(3)一种新的(Z)- n -芳基嘧啶合成方法。

1.Synthesis of the Physiological Active Terpenes. (1)Synthesis of Eudesman-alpha-methylene-6,12-olide and -8,12-olide by Intra molecular Cycization of Allylic Silylated Aldehydes. (2)Synthetic Method of alpha-Methylene-gamma-lactones Fused to Medium and Large Membered Rings by Intramolecular Cyclization of Formylated Allylhalide (3)Synthesis of Physiological Active Eremophilanes: Cinalyratol Acetate, Aristol-9-en-3-ol and Debneyol.2.Studies on the Microbial Transformations of alpha-Santonin and 11-Dehydro- alpha-santonin. (1)Microbial Hydroxylation of Santonin by Asoeriaus niger. (2)Microbial Hydroxylation of 11- Dehydrosantonin by Asperigus niger.3. alpha,beta-Epoxy Sulfoxides as Useful Intermediates in Organic Synthesis. (1)A Novel Synthesis of alpha-Substituted Carbonyl Compounds, alpha,beta-Unsaturated Ketones, and Esters from Carbonyl Compounds with Carbon Homologation Through alpha,beta-Epoxy Sulfoxides. (2)Magnesium Salt Induced Opening of alpha,beta-Epoxy Sulfoxides. Synthesis of alpha-Chloroketones, alpha-Alkoxyketones. (3)A Novel Synthegis of alpha-Acyl-, 3-Keto-, and Spiro-Cyclic Ethers via Ring-opening alpha,beta-Epoxy Sulfoxides by Hydroxyl Group. (4)A Novel Steroselective Synthesis of (E 1-Acylbutadienes from 1-Chloro alkyl Phenyl Sulfoxides and 4-(Phenylthio)butanal Through alpha,beta-Epoxy Sulfoxides . (5)A Novel Method Annulation Through alpha,beta- Epoxy Sulfoxides with aid of Intramolecular Radical Cyclization. (6)A Novel Synthesis of Aldols and Through the Enolates from alpha,beta-EPOXY Sulfoxides.4.Novel Asymmetric Synthesis Using Optical Active p-Tolylsulfinyl Group as a Chiral Auxiliary. (1)A Novel Synthesis of Chiral Epoxides and Allylic Alcohols. (2)The Practical Procedure of 1-Chloro-p-tolylsulfoxides and a Novel As Asymmetric Synthesis of (+)-Disparule and (-)-trans-Disparule. (3)A Novel Synthesis of (Z)-N-Arylaziridines.