Studies on the Synthesis of Physiological Active Terpenes and Development of New Synthetic Methods

1.生理活性萜类化合物的合成。（1）通过烯丙基甲硅烷基化醛的分子内环化合成桉烷-α-亚甲基-6，12-酮和-8，12-酮。（2）通过烯丙基卤的分子内环化合成α-亚甲基-γ-内酯的方法（3）具有生理活性的艾里莫芬烷类化合物：醋酸辛那利醇、Arizona-9-en-3-ol和Debneyol的合成。（1）黑胸蛙（Asoeriaus尼日尔）对Santonin的微生物羟基化作用。（2）黑曲霉对11-脱氢山道根素的微生物羟基化作用。作为有机合成中有用中间体的α，β-环氧亚砜。(1)Aα-取代羰基化合物、α，β-不饱和酮和酯的新合成，由羰基化合物通过α，β-环氧亚砜进行碳同系化。（2）镁盐诱导的α，β-环氧亚砜的开环。α-氯代酮、α-烷氧基酮的合成。(3)A通过羟基开环α，β-环氧亚砜合成α-酰基-、3-酮基-和螺环醚。(4)A由1-氯代烷基苯亚砜和4-（苯硫基）丁醛通过α，β-环氧亚砜立体选择性合成（E）-1-酰基丁二烯的新方法(5)A通过α，β-环氧亚砜借助于分子内自由基环化的新方法。(6)A由α，β-环氧亚砜合成羟醛及其烯醇的新方法。4.以光学活性的对甲苯亚磺酰基为手性助剂的不对称合成新方法。(1)A手性环氧化物和烯丙醇的合成新方法。（2）1-氯-对甲苯基亚砜的合成及（+）-二异戊烯和（-）-反式二异戊烯的不对称合成。(3)A（Z）-N-芳基氮杂环丙烷的合成新方法

1.Synthesis of the Physiological Active Terpenes. (1)Synthesis of Eudesman-alpha-methylene-6,12-olide and -8,12-olide by Intra molecular Cycization of Allylic Silylated Aldehydes. (2)Synthetic Method of alpha-Methylene-gamma-lactones Fused to Medium and Large Membered Rings by Intramolecular Cyclization of Formylated Allylhalide (3)Synthesis of Physiological Active Eremophilanes: Cinalyratol Acetate, Aristol-9-en-3-ol and Debneyol.2.Studies on the Microbial Transformations of alpha-Santonin and 11-Dehydro- alpha-santonin. (1)Microbial Hydroxylation of Santonin by Asoeriaus niger. (2)Microbial Hydroxylation of 11- Dehydrosantonin by Asperigus niger.3. alpha,beta-Epoxy Sulfoxides as Useful Intermediates in Organic Synthesis. (1)A Novel Synthesis of alpha-Substituted Carbonyl Compounds, alpha,beta-Unsaturated Ketones, and Esters from Carbonyl Compounds with Carbon Homologation Through alpha,beta-Epoxy Sulfoxides. (2)Magnesium Salt Induced Opening of alpha,beta-Epoxy Sulfoxides. Synthesis of alpha-Chloroketones, alpha-Alkoxyketones. (3)A Novel Synthegis of alpha-Acyl-, 3-Keto-, and Spiro-Cyclic Ethers via Ring-opening alpha,beta-Epoxy Sulfoxides by Hydroxyl Group. (4)A Novel Steroselective Synthesis of (E 1-Acylbutadienes from 1-Chloro alkyl Phenyl Sulfoxides and 4-(Phenylthio)butanal Through alpha,beta-Epoxy Sulfoxides . (5)A Novel Method Annulation Through alpha,beta- Epoxy Sulfoxides with aid of Intramolecular Radical Cyclization. (6)A Novel Synthesis of Aldols and Through the Enolates from alpha,beta-EPOXY Sulfoxides.4.Novel Asymmetric Synthesis Using Optical Active p-Tolylsulfinyl Group as a Chiral Auxiliary. (1)A Novel Synthesis of Chiral Epoxides and Allylic Alcohols. (2)The Practical Procedure of 1-Chloro-p-tolylsulfoxides and a Novel As Asymmetric Synthesis of (+)-Disparule and (-)-trans-Disparule. (3)A Novel Synthesis of (Z)-N-Arylaziridines.