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Studies on immunopathological, epidemiological analysis and control of schistosomiasis japonica in the endemic area around Tung-ting lake.

环洞庭湖日本血吸虫病流行区免疫病理学、流行病学分析及防治研究

基本信息

批准号：
63044152
负责人：
KOYAMA Tsutomu
金额：
$ 1.92万
依托单位：
National Institute of Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Overseas Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至无数据
项目状态：
已结题

项目摘要

Joint research on immunopathological, epidemiological analysis and control of schistosoma japonica in the endemic area around Tung-ting lake has been commenced in 1988. 1. The selection of three kinds of schistosomiasis foci such as (a) an area in high prevalent phase, (b) one in low prevalent phase and (c) one under controled phase for our researches. Milo-City, Mantang and Linxiang areas have been selected as pilot foci corresponding to (A), (B) and (C), respectively. Some comparative analysis of present epidemiological situations for humans and vector snails were made among above foci. 2. Immunopathological data of hepatic carcinoma and liver cirrhosis related to the disease were analyzed on the patients both in China and in Japan. And it was clarified that the question whether the disease is a cause of primary carcinoma of liver or not is still inconclusive but the close relation between the disease and liver cirrhosis is clearly significant. 3. Aiming at the biological control of vector sanils, the detection of protozoan parasites of snail was tried in the endemic area of schistosomiasis. A kind of ciliate found is now being examined on its pathogenesity.

1988年开始在洞庭湖流行区进行日本血吸虫病的免疫病理学、流行病学分析和防治的联合研究。1.选择血吸虫病高流行区、低流行区和控制区三种疫源地进行研究。选择汨罗市、满堂和临湘地区分别作为对应于（A）、（B）和（C）的试点疫源地。对上述疫源地人群和媒介钉螺的流行现状进行了比较分析。2.分析了中国和日本肝癌及肝硬化患者的免疫病理学资料。阐明了本病是否为原发性肝癌的病因尚不明确，但本病与肝硬化的密切关系是有明确意义的。3.为了开展媒介钉螺的生物防治，在血吸虫病流行区进行了钉螺原虫检测的尝试。目前正在对发现的一种纤毛虫进行致病性研究。