Studies on immunopathological, epidemiological analysis and control of schistosomiasis japonica in the endemic・area around Dong-ting lake.

新选定的疫源地为：(A)高流行区；(B)低流行型；(C)几乎控制了一个。(A)区、(B)区和(C)区日本血吸虫卵阳性率分别为65.4%、12.2% ~ 18.3%和0%。(C)血清学检测（COPT和IHA）的阳性率为6.5%。在吡喹酮治疗前后，用酶联免疫吸附法对部分患者进行血清学检测。在治疗的六个月内，出现了一个显著的降低抗体滴度针对鸡蛋抗原。对三种杀螺剂在实验室和田间的效果进行了研究。其中Cartap在田间试验中表现出较高的活性。同时对病媒蜗牛的原生动物寄生虫进行了调查，以期对病媒蜗牛进行生物防治。我们研究了中国患者抗卵抗体独特型的异质性。对血清样品进行体外血吸虫特异性T淋巴细胞活化试验。结果表明，在某些患者体内存在一种调节性独特型抗体，该试验对分析日本血吸虫病的免疫病理机制可能是有用的。本文对中国和日本血吸虫病和乙型肝炎患者的肝癌病理特征进行了研究。

The newly selected foci were: (A) high prevalent area; (B) low prevalent one; and (C) nearly controlled one. The positive rates of the Schistosoma japonicum egg were 65.4%, 12.2-18.3% and 0% in areas (A), (B) and (C), respectively. In (C), the positive rate of 6.5% was obtained as a result of serological tests (COPT and IHA). Some of the people with the eggs were serologically tested by means of ELISA before and after the treatment with praziquantel. Within six months of the treatment, there occurred a remarkable decrease of the antibody titer against the egg antigen. Three kinds of molluscicides were investigated for their effects in laboratories and fields. Cartap among them showed high activity in field trials. The protozoan parasites of vector snails were also investigated for the purpose of biological control. We investigated heterogeneity of idiotypes of anti-egg antibodies in Chinese patients. The serum samples were tested for activating schistosome-specific T lymphocyte in vitro. The result suggests that there is a regulatory idiotypic antibodies in some patients and that the test seems useful for the analysis of immunopathological mechanisms in schistosomiasis japonica. Pathological features of hepatic carcinoma related to schistosomiasis and hepatitis B were studied on the patients both in China and in Japan.