REACTIVITY CONTROL IN ORGANIC CHEMISTRY

来自代表性大学和研究机构的24位领先的物理有机化学家组成了一个合作研究项目团队。该团队的主要目标是尽可能在定量意义上建立对控制有机化合物反应性的因素的全面理解。方法从1)结构变化效应的传递；2)反应化学物质的化学性质和特性；3)种间相互作用的检测和量化；4)涵盖分子聚集和簇的反应场的识别和表征。项目团队的成员既参与个人领域的研究，也参与有趣问题相互关联方面的讨论与合作。最终研究报告的日语文本中引用的各种方法中的192个参考文献说明了结果。代表性的结果是a)阐明了有机阳离子和过渡态共有的电子需求程度；b)从实验和理论两方面阐明了分子缔合在Griganard反应、Wittig反应、S_NAr反应等亲核有机反应中的重要性。

Twenty four leading physical organic chemists in representative universities and research institutions made up a cooperative research project team.The major aim of the team is to try to establish a comprehensive understanding of the factors governing the reactivity of organic compounds in quantitative sense as far as possible. Approaches are made from the stand points of 1)transmission of the effects of the structural change: 2)chemistry of reactive chemical species and identities: 3)detection and quantilization of interspeclies interaction: 4)identification and characterization of the reaction field covering the topics of molecular aggregates and clusters.Members of the project team are involved both the research of the individual field and the discussion-cooperation of the interlocking aspects of the interesting problems. The results are exemplified by the 192 references in the varieties of the approach which are cited in the Japanese text of the final research report. Representative results are a)the elucidation of the degree of the electron demand common to organic cationic species and transition state; b)elucidation of the importance of the molecular association in the nucleophilic organic reactions such as Griganard Reaction, Wittig Reaction, S_NAr Reaction etc. through both experimental and theoretical approach.