Research on pathogenesis, epidemiology and treatment for HTLV-I related neurological disorders

HTLV-I相关神经系统疾病的发病机制、流行病学和治疗研究

• 批准号: 63304042
• 负责人: IGATA Akihiro
• 金额: $ 17.41万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63304042/
• 关键词: HTLV-I; HAM; TSP; HTLV-I-Associated; Spastic Paraparesis; Retrovirus; Polyarthritis; alpha-Interferon; レトロウィルス; HILV-I associated Myelopathy

Our recent investigation revealed that human lymphotropic virus type I (HTLV-I) can cause a chronic neurological disorder which was named HTLV-I-associated myelopathy(HAM) by Osame et al in 1986. The purpose of this project was to elucidate the pathomechanism, epidemiology and treatment of HTLV-I related neurological disorders including HAM. This research project could obtain the following fruitful results: 1) The viruses detected in ATL and HAM are identical on DNA blotting. 2) Increased replication of HTLV-I in HAM was observed. 3) HLA haplotype-linked high immune responsiveness against HTLV-I was observed in HAM, when compared with ATLL. 4) The identity of HAM and tropical spastic paraparesis was established. 5) High incidence of pulmonary involvement, polyarthritis, and uveitis was found in HAM. 6) alpha-interferon and prednisolone were found to be effective for the treatment of HAM.

我们最近的调查显示，人类嗜淋巴病毒I型（HTLV-I）可引起慢性神经系统疾病，Osame等人于1986年将其命名为HTLV-I相关脊髓病（HAM）。本项目旨在阐明HTLV-I相关神经系统疾病（包括HAM）的发病机制、流行病学及治疗。本研究项目取得了以下丰硕的成果：1)ATL和HAM检测到的病毒在DNA印迹上是相同的。2)观察到HTLV-I在HAM中的复制增加。3)与ATLL相比，在HAM中观察到HLA单倍型相关的对HTLV-I的高免疫应答。4)确定了HAM与热带痉挛性麻痹的同一性。5) HAM的肺部受累、多发性关节炎、葡萄膜炎发生率高。6) α -干扰素和强的松龙治疗HAM有效。

项目成果

Mitsuhiro Osame,;Akihiro Igata.,et al: "Neuroimmunological Diseases--Recent Advances in Pathogenesis and Treatment Clinica-Epidemiological Study of HTLV-I-Associated Myelopathy in Japan" University of Tokyo Press, 1-409 (1988)

Mitsuhiro Osame,;Akihiro Igata.,et al:“神经免疫疾病 - 日本 HTLV-I 相关脊髓病发病机制和治疗临床流行病学研究的最新进展”东京大学出版社，1-409 (1988)

Akizuki S, Yoshida S, Setoguchi M, et al: "The neuropathology of human T-lymphotropic virus type I-associated myelopathy" "HTLV-I and the Nervous System" 253-260, 1989 Alan R. Liss, Inc.

Akizuki S、Yoshida S、Setoguchi M 等人：“人类 T 淋巴细胞病毒 I 型相关脊髓病的神经病理学”“HTLV-I 和神经系统”253-260，1989 Alan R. Liss, Inc.

納光弘: "HAM(HTLV-I骨髄症)" Medical Immunol. 17. 433-437 (1989)

Hiroshi Namitsu：“HAM（HTLV-I 脊髓病）”《医学免疫学》17. 433-437 (1989)

Akihiro Igata.: "Unusual Occurrences as Clues to Cancer Etiology HTLV-I-associated Myelopathy: An Overview" Japan Sci Soc.Press, 181-186 (1988)

Akihiro Igata.：“异常事件作为癌症病因学 HTLV-I 相关脊髓病的线索：概述”Japan Sci Soc.Press，181-186 (1988)

Kitajima I,Maruyama I,Maruyama Y,et al: "Polyarthritis in HTLV-I associated myelopathy(HAM)." Arthritis Rheum. 32. 1342-1344 (1989)

Kitajima I、Maruyama I、Maruyama Y 等人：“HTLV-I 相关脊髓病 (HAM) 中的多关节炎。”