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Studies on the determination of etiology of dementia and development of new diagnostic methods, therapies and drugs.

研究痴呆症病因的确定以及新诊断方法、疗法和药物的开发。

基本信息

批准号：
63440035
负责人：
MARUYAMA Shoichi
金额：
$ 1.98万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

Three-year Study ResultsWe conducted various studies to determine the etiology of dementia and develop new diagnostic methods, therapies and drug over the 3-year period between 1988 and 1990 and obtained the results (most of which are new findings) summarized below.1. Neurophysiological studies ; Latency for event-related potential (P300), long latency reflex (LLR), auditory brain stem response (ABR) and visual evoked potential (VEP) increased significantly in patients with various neurological disorders in which dementia or impaired cerebral function is suspected, including not only Alzheimer-type dementia (ATD) and multi-infarct-dementia (MID) but also motorneuron diseases, dialysis encephalopathy and subacute combined degeneration of the spinal cord.2. Neuropsychological studies. : In patients with the above-mentioned diseases, Hasegawa's Dementia Scale, Mini-Mental State and WAIS showed significant correlation with P300 and other neurophysiological tests.3. Neurobiochemical studies … More : Vasopressin (AVP) and thyrotropin releasing hormone (TRH) showed positive correlation with age in the MID and control groups and negative correlation in the ATD group, suggesting the presence of differences in the biochemical role of neuro-peptides in the ATD group and other groups. Elucidation of these differences has come into the spotlight as a major study objective.4. Studies related to blood coagulation : Platelet aggregation, beta-TG, PF4, prostanoids and molecular markers showed abnormalities in the MID group.5. Neuropathological studies : It was shown that cell density in Meynert's nuclei which project cholinergic neurons is decreased in patients with Pick disease with dementia and that micromorphological and immunohistological findings of senile plaques, amyloid beta-protein and tau-protein are related to dementia in the brain of progressive supranuclear palsy.6. Pharmacotherapy and prevention of dementia : VAP administration resulted in significant increases in VAP and TRH concentrations in the cerebrospinal fluid in dementia patients who showed improvement. It was also confirmed that reversal of blood coagulation abnormality using drugs and maintenance of appropriate blood pressure are very important in preventing MIS manifestation. Less

三年研究结果我们在1988年至1990年的三年期间进行了各种研究，以确定痴呆症的病因，并开发新的诊断方法，治疗方法和药物，并获得了以下总结的结果（其中大部分是新发现）。神经生理学研究;事件相关电位（P300）、长潜伏期反射（LLR）、听觉脑干反应（ABR）和视觉诱发电位（VEP）潜伏期在怀疑为痴呆或脑功能受损的各种神经系统疾病患者中显著增加，这些疾病不仅包括阿尔茨海默型痴呆（ATD）和多发梗塞性痴呆（MID），而且包括运动神经元疾病，透析性脑病和亚急性脊髓联合变性.神经心理学研究。长谷川痴呆量表、简易精神状态量表、WAIS与P300等神经电生理检测结果有显著相关性.神经生化研究 ...更多信息 MID组和对照组的加压素（AVP）和促甲状腺激素释放激素（TRH）与年龄呈正相关，ATD组与年龄呈负相关，提示ATD组与其他各组神经肽的生化作用存在差异。阐明这些差异已成为一个主要的研究目标的聚光灯下。凝血功能相关研究：MID组血小板聚集、β-TG、PF 4、前列腺素及分子标志物异常.神经病理学研究：研究表明，皮克病伴痴呆患者投射胆碱能神经元的Meynert核细胞密度降低，老年斑、淀粉样β蛋白和tau蛋白的微形态学和免疫组织学发现与进行性核上性麻痹脑中的痴呆有关.药物治疗和预防痴呆：VAP给药导致痴呆患者脑脊液中VAP和TRH浓度显着增加，这些患者表现出改善。研究还证实，使用药物逆转凝血异常和维持适当的血压对预防MIS表现非常重要。少