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Physiological and Psychological Study on Reorganization of the Visual Function in the Albino Rat with One Eye Removed at Early Postnatal Days

摘除一只眼的白化大鼠生后早期视觉功能重组的生理和心理研究

基本信息

批准号：
63510042
负责人：
YAGI Fumio
金额：
$ 0.9万
依托单位：
Miyagi University of Education
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

Our previous studies have shown that albino rats with one eye enucleated soon after birth (OEB) could relearn a black-white discrimination task faster than rats with one eye enucleated at maturity (OET) when relearning was conducted after the visual cortex lesions contralateral to the remaining eye, whereas both types of rats failed to relearn a pattern discrimination.The present study was then undertaken to examine the question of whether this kind of behavioral reorganization is also demonstrated in a light-dark discrimination of albino rats and in a pattern discrimination of hooded rats, and the following new original findings were established.1. As to a light-dark discrimination in albino rats, both OEBs and OETs could acquire the habit more quickly after the visual cortex lesions contralateral to the remaining eye and after the bilateral visual cortex lesions, and they also be able to relearn after both types of visual cortex lesions. These results indicate that in a light-dark discrimination of albino rats it was not demonstrated the behavioral expression of morphological and physiological changes which are produced by monocular enucleation in the early postnatal days.2. On the other hand, however, in a pattern discrimination of hooded rats, OEBs could acquire and relearn the habit faster than OETs after the visual cortex lesions contralateral to the remaining eye, hence indicating that functional enhancement in the uncrossed visual nervous system produced by early monocular enucleation could actively be involved in a pattern discrimination of hooded rats. Investigations trying to measure the visual acuity of the hooded rat with one eye removed at birth are now under progress in our laboratory in order to clarify the nature of behavioral expression of functional enhancement in the uncrossed visual pathways by early monocular enucleation.

我们以前的研究表明，出生后不久一只眼去核的白化大鼠(OEB)比一只成熟时一只眼去核(OET)的大鼠在对侧视皮层损伤后进行重新学习时，能够更快地重新学习黑白辨别任务，而两种类型的大鼠都未能重新学习模式辨别。本研究随后进行了这种行为重组是否也在白化大鼠的明暗辨别和蒙面大鼠的模式辨别中表现出来的问题，并建立了以下新的原创性发现。对于白化大鼠的明暗辨别，OeBS和OETs在对侧视皮层损毁和双侧视皮层损毁后都能更快地习得，并且在两种视皮层损毁后都能重新学习。这些结果表明，在白化大鼠的明暗辨别中，没有表现出出生后早期单眼摘除所产生的形态和生理变化的行为表现。另一方面，在戴帽大鼠的模式识别中，OeBS比OETs更快地获得和重新学习习惯，这表明早期单眼摘除对未交叉的视觉神经系统产生的功能增强可能积极地参与了戴帽大鼠的模式识别。我们实验室目前正在对出生时摘除一只眼睛的蒙面大鼠的视力进行测量，以澄清早期单眼摘除在非交叉视觉通路中功能增强的行为表现的本质。