Studies on new paralytic shellfish toxin producind dinoflagellates.

新产麻痹性贝类甲藻毒素的研究.

• 批准号: 01044017
• 负责人: OSHIMA Yasukatsu
• 金额: $ 1.09万
• 依托单位: Faculty of Agriculture, Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01044017/
• 关键词: Paralytic Shellfish Toxins; Toxin Profile; Dinoflagellate; Gymnodinium catenatum; Alexandrium minutum; Alexandrium tamarense

Paralytic shellfish poisoning causes serious hazard to both public health and fishery industries in many countries. In this collaborative study, biological and toxigenic natures of a newly found toxic dinoflagellate Gymnodinium catenatum were investigated.The growth, sexuality and cyst production of the organism were fully demonstrated. HPLC analysis indicated that G. catenatum from Tasmania produced C1-C4 toxins as major components with slight amounts of rather unique decarbamoyltoxins. A new toxin found in both dinoflagellate and toxic mussels was shown to be 13-deoxydecarbamoylsaxitoxin by spectral analysis. Toxicity and stability of major toxins (C1-C4) as well as toxin profiles of Alexandrium minutum and A. tamarense from Australia was also clarified.

麻痹性贝类中毒对许多国家的公共卫生和渔业造成严重危害。在这项合作研究中，研究了一种新发现的有毒双鞭毛藻裸子的生物学和产毒特性。充分展示了该生物的生长、性和囊肿的产生。HPLC分析表明，产自塔斯马尼亚岛的悬藤以C1-C4毒素为主，并含有少量独特的脱氨基毒素。在甲藻和有毒贻贝中均发现了一种新的毒素——13-脱氧脱碳贝毒素。阐明了产自澳大利亚的亚历山Alexandrium minutum和A. tamarense主要毒素（C1-C4）的毒性和稳定性，以及毒素谱。

项目成果

Y.Oshima,M.Hirota,T.Yasumoto,G.Hallegraeff,S.Blackburn&D.Steffensen: "Production of paralytic shellfishtoxins by the dinoflagellate Alexandrium minutum Halim from Australia." Nippon Suisan Gakkaiーshi. 55. 925 (1989)

Y. Oshima、M. Hirota、T. Yasumoto、G. Hallegraeff、S. Blackburn 和 D. Steffensen：“澳大利亚微小亚历山大藻产生麻痹性贝类毒素”，55. 925 (1989)。

Y.Oshima,T.Yasumoto,S.Blackburn&G.Hallegraeff: "Comparison of toxin profiles of dinoflagellate Gymnodinium catenatum from various countries." Journal of Phycology.

Y.大岛,T.安本,S.布莱克本

Y. Oshima, M. Hirota, T. Yasumoto, G. Hallegraeff, S. Blackburn and D. Steffensen: "Production of paralytic shellfishtoxins by the dinoflagellate Alexandrium minutum Halim from Australia." Nippon Suisan Gakkaishi. 55. 925 (1989)

Y. Oshima、M. Hirota、T. Yasumoto、G. Hallegraeff、S. Blackburn 和 D. Steffensen：“来自澳大利亚的甲藻微小亚历山大藻 Halim 产生麻痹性贝类毒素。”

Y. Oshima, T. Yasumoto, G. Hallegraeff and S. Blackburn: "Comparison of toxin profiles of dinoflagellate Gymnodinium catenatum from various countries." Journal of Phycology (in preparation).

Y. Oshima、T. Yasumoto、G. Hallegraeff 和 S. Blackburn：“来自不同国家的甲藻链状裸甲藻毒素谱的比较。”

Y.Oshima,K.Sugino,H.Itakura,M.Hirota&T.Yasumoto: "Comparative studies on paralytic shellfish toxin profile of dinoflagellate and bivalves.pp 391ー396 In Toxic Marine Phytoplankton." Elsevier Science Publishing Co.New York, 554 (1990)

Y.Oshima、K.Sugino、H.Itakura、M.Hirota 和 T.Yasumoto：“甲藻和双壳类麻痹性贝类毒素谱的比较研究。第 391-396 页，有毒海洋浮游植物，爱思唯尔科学出版公司，纽约，554” (1990)