Synthetic Studies on the Integrated Control Function of the Masticatory System

研究结果表明：1）新生小鼠眶下神经的切断导致初级和次级神经元的变性; 2）尾毛神经和向日葵神经的切断导致小鼠咬力的下降。3)HRP标记的中间神经元出现在三叉神经运动核的网状结构中。4)在豚鼠上证实了从皮层前、后咀嚼区到脑干中枢模式发生器的不同神经元回路。5)证明了皮层诱导舌-下颌运动的时间和方式是由脑机制综合控制的。6)后腭粘膜上的机械应力被传递到中央模式发生器，模式信息被发送到下颌闭合运动神经元和舌运动神经元，进行协同运动。7)在负荷释放大鼠中，蛋白质和DNA合成下降， ...更多信息 Zn的含量增加，抗重力肌肉和内脏重量增加。8)摄食性和厌恶性味觉刺激引起的舌下颌运动与腭部机械应力引起的舌下颌运动相对应。9)研制了一种具有下颌运动测量机构和学习能力的咀嚼机器人。10)脉冲电磁场诱导的成骨样细胞[ ^3H] TdR掺入依赖于cGMP依赖的蛋白激酶途径。11)骨细胞在破骨细胞的活化和骨吸收的调节中起重要作用。12)在3个大气压下持续施加压缩压力导致负骨代谢。13)从生活在1，100 m深海的Calyptogena sp.（Mullusca）中单独分离出了硫杆菌，并对其16 S RNA序列进行了研究。制定了优先领域科学研究资助计划（1992年）的跨学科研究项目[咀嚼相关信息：其生物调节和发展]的计划，并将提交。少

Summary of the research results obtained is as follows : 1) The axotomy of the infraorbital nerve in newborn mice led to the degeneration of the primary and secondary neurons ; and 2) that of Urotrichus and Suncus caused the decline of biting ability. 3) HRP-labelled interneurons were observed in the reticular formation after the trigeminal motor nucleus exposed to HRP. 4) Different neuron circuits from the anterior and posterior masticatory area of the cortex to the central pattern generator in the brain stem were proved in guinea pig. 5) Brain mechanism by which the timing and pattern of the linguo-mandibular movements induced cortically are integratedly controlled was proved. 6) The mechanical stress on the posterior palatal mucosa was conveyed into the central pattern generator and the patterned information are sent to the jaw-closing motor and lingual motor neurons to conduct the co-operated movement. 7) In the load-discharged rats, the decline of protein and DNA synthsses, supply … More of Zn, and the weight of antigravity muscles and internal organs occurred. 8) Ingestive and aversive taste-stimulation-induced linguo-mandibular movements correspond to those induced by palatal mechanical stress. 9) The mastication robot bearing a jaw-movement measuring mechanism and learning ability was developed. 10) The incorporation of [ ^3H] TdR of the osteoblast like cells induced by the pulsed electromagnetic field is dependent on the cGMP-dependent protein kinase pathway. 11) The osteocytes play an important role in the activation of osteoclasts and the regulation of bone resorption. 12) The continuously-applied compressive pressure at 3 atmosphere led to negative bone metabolism. 13) The Thiobacillus sp. was singly separated from the Calyptogena sp. (Mullusca), living in 1, 100 m deep-sea, and the sequence of its 16S RNA was investigated.The program of the interdisciplinary research project [ Mastication-related information : its bio-regulation and development ], by Grant-In-Aid for Scientific Research on Priority Areas (1992) was drawn up to be submitted. Less