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Fundamental study on humoral factors regulating postnatal development, aging and maintenance of masticatory system

体液因子调控后天发育、衰老及咀嚼系统维持的基础研究

基本信息

批准号：
12671771
负责人：
MAEDA Norihiko
金额：
$ 2.11万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The various factors are involved in the development, aging and maintenance of the masticatory system. In the present study, we investigated effects of various humoral factors, and those of the lack of the sensory input from the sensory endings in the periodontal ligaments, resulted from tooth-loss on the regulatory system of the jaw movement. We obtained following results and conclusions : early partial loss of dentition induce the inevitable decrease in the sensory input to the Mo5 motoneurons, via Me5 and Su5 from periodontal sensory endings, then might result in the precocious reduction in masticatory motoneurons in the Mo5 that innervate the masseter muscle, and significant effects on the decrease in the number may be easily caused only by the partial tooth-loss during an early limited period in the postnatal development of animals. Moreover, it is reasonably suggested by the present results that a functional decrease in the masseter muscle, due to the atrophy of the extrafusal muscle fibers, secondarily cause the reduction in the number of Me5 neurons innervating muscle spindles in the masseter muscle. The present study also suggests that the degeneration of periodontal afferents may start at a comparatively early period during the postnatal life even in healthy mice. In these mice, we found that various humoral factors including sex hormones and FGFs are involved in aging and the maintenance of the masticatory system.

咀嚼系统的发育、老化和维持与多种因素有关。在本研究中，我们研究了各种体液因素的影响，以及牙周膜感觉末梢的感觉输入的缺乏，导致牙齿缺失的下颌运动的调节系统。我们得到了以下结果和结论：牙列早期部分缺失导致牙周感觉末梢通过Me5和Su5向Mo5运动神经元的感觉输入不可避免地减少，然后可能导致支配咬肌的Mo5咀嚼运动神经元的过早减少，在动物出生后发育的早期有限时期，仅部分牙齿脱落就容易引起数量减少的显著影响。此外，它是合理的建议，由本研究结果，咬肌功能下降，由于梭外肌纤维的萎缩，其次导致减少的Me5神经元支配的咬肌肌梭的数量。本研究还表明，牙周膜传入纤维的退化可能在出生后的一个相对较早的时期开始，即使在健康的小鼠。在这些小鼠中，我们发现包括性激素和FGF在内的各种体液因素参与衰老和咀嚼系统的维持。