Mass Examination for Osteofluorosis and Osteoporosis,Using Dual-Energy X-ray Absorptiometry

使用双能 X 射线吸收测定法对氟骨症和骨质疏松症进行大规模检查

• 批准号: 01440037
• 负责人: TSUONODA Humio
• 金额: $ 14.34万
• 依托单位: Iwate medical university
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01440037/
• 关键词: Bone densitometry; Dual-energy X-ray absorptiometry; Osteoporosis; Osteofluorosis; Bone mineral density; Mass examination for osteoporosis; Normal value of bone density; 骨粗鬆症スクリ-ニング

In response to efforts to prevent osteofluorosis (osteosclerosis) and osteoporosis, the incidence of which is rapidly increasing due to industrialization and aging of the society, we established a mass examination method using a bone densitometer to test for two types of osteopathies. Basic studies were conducted using a Norland XR-26 (USA) system for dual-energy X-ray absorptiometry (DEXA); this system is considered to be the most suitable for measurement of bone mineral content from the standpoint of sensitivity, accuracy, measurement time, and noninvasive properties. The fluctuation coefficients of measurements were less than 1% in vitro and less than 2% in vivo with good precision. Regarding the accuracy of measurements, a linear relationship between measured values of standard phantoms of quantitative computed tomography (QCT) and nominal values was found. Furthermore, there was essentially no scattering radiation in the measurements performed with a thermoluminescence dosimeter. … More Various regions of the body were evaluated in the determination of the most appropriate region for mass examination, and the anterior-posterior direction of the lumbar spine (L_2-L_4) was found to be optimum for examination in terms of required time, accuracy, and ease of measurement. The bone mineral density (BMD) of the region in normal adults is often higher than 1.000g/cm^2; although essentially no change in BMD with age was found in males, a tendency toward rapid decrease was observed in females in their 40s and 50s. With respect to osteofluorosis, BMD was measured in residents living in areas where the fluoride content in drinking water is high--areas scattered throughout the Homan river Basin in North Kyushu. The results of measurements indicated a certain correlation between consumption of water containing a high level of fluoride and an increase in BMD. The diagnostic system was mounted on an examination vehicle, and we conducted mass examinations in the field. Measurements made in the anterior- posterior direction on the lumbar spine required approximately 10min.per person; thus examination of 40 persons per day was possible. From the measurements of approximately 300 persons for osteoporosis the value of BMD was found to be 1SD lower than a set value established by us in 16.1% of female adults. Also, behavioral interviews carried out on people during the investigation revealed that conventionally reported risk factors for osteoporosis, trends such as lack of calcium intake or lack of exercise, were found among low-BMD individuals. In the present study, a method using DEXA and a vehicle-mounted bone densitometer for mass examination of osteofluorosis and osteoporosis has been established and found to be effective in the prevention of osteopathies. Less

由于工业化和社会老龄化，氟骨症（骨质疏松症）和骨质疏松症的发病率迅速增加，为了预防这两种疾病，我们建立了一种使用骨密度计测试两种类型的骨病的群众检查方法。使用Norland XR-26（美国）双能X射线吸收测定法（DEXA）系统进行基础研究;从灵敏度、准确度、测量时间和无创性的角度来看，该系统被认为是最适合测量骨矿物质含量的系统。体外测量波动系数小于1%，体内测量波动系数小于2%，具有良好的精密度。关于测量的准确性，定量计算机断层扫描（QCT）标准体模的测量值与标称值之间存在线性关系。此外，在用热释光剂量计进行的测量中，基本上没有散射辐射。 ...更多信息 在确定最适合进行肿块检查的部位时，对身体的各个部位进行了评价，发现腰椎（L_2-L_4）的前后方向在所需时间、准确性和测量方便性方面是最佳的检查方向。正常成年人该区域的骨矿物质密度（BMD）通常高于1.000 g/cm ^2;虽然在男性中基本上没有发现BMD随年龄的变化，但在40和50岁的女性中观察到BMD迅速下降的趋势。关于氟骨症，对居住在饮用水中氟化物含量高的地区-分散在北九州的满川流域的地区-的居民进行了BMD测量。测量结果表明，含氟量高的水的消费量和骨密度的增加之间有一定的相关性。诊断系统安装在检查车上，我们在现场进行了大规模检查。在腰椎前后方向上进行的测量大约需要10分钟。每人;因此，每天可以检查40人。从大约300人的骨质疏松症的测量中，发现16.1%的成年女性的BMD值比我们建立的设定值低1 SD。此外，在调查期间对人们进行的行为访谈显示，在低BMD个体中发现了传统报道的骨质疏松症风险因素，如缺乏钙摄入或缺乏锻炼等趋势。在本研究中，一种方法，使用DEXA和车载骨密度仪为群众检查氟骨症和骨质疏松症已被建立，并发现是有效的预防骨病。少

项目成果

立身 政信: "骨粗鬆症の発生要因に関する疫学的研究" 岩手公衆衛生学会誌. 4. 23-30 (1992)

Masanobu Tatsumi：“骨质疏松症原因的流行病学研究”岩手公共卫生学会杂志4. 23-30 (1992)。

小野田 敏行: "DEXA法による骨粗鬆症集団健康診断について(第2報)生体の長期追跡時における誤差の検討" 日本公衆衛生学雑誌. 38. 464 (1991)

Toshiyuki Onoda：“关于使用 DEXA 方法进行骨质疏松症人群健康诊断（第二次报告）活体长期随访过程中的错误检查”日本公共卫生杂志 38. 464 (1991)。

立身 政信: "DEXA法による骨粗鬆症の集団検診に関する研究(第3報)農村地域住民の集団検診結果からみた発症要因の検討" 日本公衆衛生学雑誌. 39. 586 (1992)

Masanobu Tachimi：“使用 DEXA 方法进行骨质疏松症大规模筛查的研究（第 3 次报告）根据农村居民大规模筛查结果检查发病因素”日本公共卫生杂志 39. 586（1992 年）。

TATSUMI,masanobu: "Study on mass-screening of osteoporosis (1)Examination of risk factors of osteoporosis through questionnaires" J.Tohoku public health assoc. 39. 29 (1990)

辰巳政信：“骨质疏松症大规模筛查的研究（1）通过问卷调查调查骨质疏松症的危险因素” J.东北公共卫生协会。

TSUNODA,humio: "Application of bone mineral measurement to mass-screening of osteoporosis" Byotai seiri. 10-8. 649-651 (1991)

Tsunoda,humio：“骨矿物质测量在骨质疏松症大规模筛查中的应用”Byotai Seiri。