A Role of Ummue-Regulatory Function on Graft Preservation in Liver Transplantation

Ummue调节功能在肝移植中移植物保存中的作用

• 批准号: 01440054
• 负责人: KOBAYASHI Michio
• 金额: $ 8.64万
• 依托单位: Oita Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01440054/
• 关键词: Liver Transplantation; Immunodepressant; Liver Preservation; Cytokine; Lipid Peroxidation; Reperfusion Injury; Sinusoidal Injury; FK506; Azathioprine; Immunosuppressant; Cyclosporine; Liver preservation; 肝温阻血

A role of immune-regulatory function on cold and warm ischemia damage of the liver was investigated using rats and pigs. Pretreatment with immunosuppressants (cylosporine, azathioprine, FK506) significantly ameliorated warm or cold ischemia/reperfusion damage of the liver. This was accompanied by suppression of TNF release, improvement of graft microcirculation and lipid peroxidation, and alleviation of hepatic sinusoidal injury. It is of note that immune-modulation of the recipient substantially improved graft function after cold preservation and transplantation. Our data suggest that the immune-modulation on the recipient is important for improving graft viability in liver tramsplantation.

本实验用大鼠和猪研究了免疫调节功能在肝脏冷、热缺血损伤中的作用。免疫抑制剂（环孢素，硫唑嘌呤，FK 506）预处理显着改善热或冷缺血/再灌注损伤的肝脏。同时抑制TNF的释放，改善移植肝微循环和脂质过氧化反应，减轻肝窦损伤。值得注意的是，受体的免疫调节在冷保存和移植后显著改善了移植物功能。我们的数据表明，在肝移植中，受体的免疫调节对于提高移植物存活率是重要的。

项目成果

Kim YI et al: "Influences of Cyclosporine Pretherapy on 90% hepate ctomezed Rats" Eur Surg Res.

Kim%20YI%20et%20al:%20"影响%20of%20环孢菌素%20治疗前%20on%2090%%20hepate%20ctomezed%20Rats"%20Eur%20Surg%20Res。

Kawano K: "A protective effect of FK506 in ischemically injured rat liver" Transplantation. 47. 143-145 (1991)

Kawano K：“FK506 对缺血性损伤的大鼠肝脏的保护作用”移植。

Goto S et al: "The Effects of Pretransplant Cyclosporine Therapy on Rats Grafted With TwelveーHour ColdーStored LiversーWith Special Reference to Reperfusion Injury" Transplantation. 52. 615-621 (1991)

Goto S 等人：“移植前环孢素治疗对十二小时冷藏肝脏移植的大鼠的影响 - 特别参考再灌注损伤” 移植。

KAWANO K: "Evidence that azathipprine,as well as cyclosporine,ameliorates warm ischemia in the rat liver" TRANSPLANTATION. 49. 1002-1003 (1990)

KAWANO K：“有证据表明氮杂噻吩碱以及环孢菌素可以改善大鼠肝脏的热缺血”移植。

Goto S: "The effects of pretransplant cyclosporine therapy on rats grafted with 12-hr cold-stored liver : with special reference to reperfusion injury" Transplantation. 52. 615-621 (1991)

Goto S：“移植前环孢素治疗对移植 12 小时冷藏肝脏的大鼠的影响：特别参考再灌注损伤” 移植。