Mast Cell-dependent Delayed Hypersensitivity (Jones-Mote type) and Analysis for Cellular Mechanism of the Response.

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I. *Mast cell-deficient W/W^v mice could develop DH reactions to MHSA and SRBC upon challenge injection on 12th day after subcutaneous sensitization with FCA and antigen. DH reactions of W/W^v and their control +/+ mice were similar however, magnitude of the reactions was found to be lower in W/W^v than +/+ mice. *Mast cells are not essential for elicitation of DH skin responses. *Possibly mast calls regulate the magnitude of the responses.II. *Delayed FPR induced by sensitization with FIA and antigen in PBS were not developed in W/W^v mice 4 weeks after sensitization. On the other hand, +/+ and C57BL/6 mice developed this type of reactions. These FPRs were not suppressed by intraperitoneal injection of ferritin, which was found to suppress elicitation of tuberculin-type of DH response in mice, just before challenge injections. *These observations suggest the presence of two distinct type of DH responses in mice: Mast cell- independent and ferritin sensitive type and mast cell-dependent and ferritin refractory type.